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德国疾病分析器数据库的基本特征及代表性

Basic characteristics and representativeness of the German Disease Analyzer database
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作者信息

Rathmann Wolfgang, Bongaerts Brenda, Carius Hans-Joachim, Kruppert Silvia, Kostev Karel

出版信息

Int J Clin Pharmacol Ther. 2018 Oct;56(10):459-466. doi: 10.5414/CP203320.

Abstract

PURPOSE

The aim of this study was to evaluate the representativeness of diagnoses in the Disease Analyzer (DA) database for major chronic diseases (cancer, dementia, diabetes).

MATERIALS AND METHODS

DA contains anonymized longitudinal data on drug prescriptions, diagnoses as well as medical and demographic data directly obtained from the computer system of a representative sample of practices throughout Germany. DA contains data from 2,498 practices with 7.8 million patients (2017). The distribution and sex-specific incidence of various cancer subsites among new cancer cases, the age- and sex-specific prevalence of dementia, and the prevalence of diabetes were assessed. National reference data were obtained from official sources.

RESULTS

Mean age (43 years) and sex distribution (47% men) of primary care patients in DA were similar to the German population. Among incident cancer cases, there was good agreement between DA data and national data with respect to the various cancer subsites (e.g., breast cancer: DA 17%; reference: 15%). Furthermore, sex distribution was largely similar. The age distribution of prevalent dementia was similar to national reference data, both in men (80 - 84 years: DA: 26.8%; reference: 27.0%) and in women (80 - 84 years: DA: 24.6%; reference: 24.1%). Diabetes prevalence in the DA (10.7%) was higher than in claims data from physicians (9.8%) or patients from statutory health insurances (9.9%).

CONCLUSION: There was a good agreement of the incidence or prevalence of major chronic diseases in the outpatient DA with German reference data. The higher diabetes prevalence in the DA is due to the increased number of outpatient visits of diabetes patients.
.

摘要

目的

本研究旨在评估疾病分析仪(DA)数据库中主要慢性病(癌症、痴呆症、糖尿病)诊断的代表性。

材料与方法

DA包含来自德国各地具有代表性的诊所计算机系统直接获取的匿名纵向药物处方、诊断以及医疗和人口数据。DA包含来自2498家诊所、780万患者的数据(2017年)。评估了新癌症病例中各种癌症亚部位的分布和性别特异性发病率、痴呆症的年龄和性别特异性患病率以及糖尿病的患病率。国家参考数据来自官方来源。

结果

DA中初级保健患者的平均年龄(43岁)和性别分布(男性占47%)与德国人口相似。在新发癌症病例中,DA数据与国家数据在各种癌症亚部位方面具有良好的一致性(例如,乳腺癌:DA为17%;参考值为15%)。此外,性别分布基本相似。男性(80 - 84岁:DA为26.8%;参考值为27.0%)和女性(80 - 84岁:DA为24.6%;参考值为24.1%)中痴呆症的年龄分布与国家参考数据相似。DA中的糖尿病患病率(10.7%)高于医生申报数据(9.8%)或法定医疗保险患者数据(9.9%)。

结论

门诊DA中主要慢性病的发病率或患病率与德国参考数据具有良好的一致性。DA中糖尿病患病率较高是由于糖尿病患者门诊就诊次数增加所致。

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