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长期冠状动脉支架置入术后的放射性肉瘤

Radiation-Induced Sarcoma following Prolonged Coronary Stent Placement.

作者信息

Vick Eric J, Clark Christopher T, Lewis James M

机构信息

College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, USA.

Department of Pathology, University of Tennessee Medical Center, Knoxville, TN, USA.

出版信息

Case Rep Surg. 2018 Aug 5;2018:2903801. doi: 10.1155/2018/2903801. eCollection 2018.

DOI:10.1155/2018/2903801
PMID:30174980
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6098899/
Abstract

Radiation exposure for the average coronary stent placement varies based on a number of factors but typically amounts to 6-11 mSv per patient (compared to 3 mSv background). As with all procedures which utilize radiation, there is an inherent risk of genetic mutation and the possible development of malignancy. Here, we present the case of a 75-year-old male who presented with an exophytic mass on his back following prolonged coronary catheterization with a radiation burn seven years prior. Biopsy of the lesion revealed the mass was consistent with an undifferentiated pleomorphic sarcoma emanating from the site of the radiation burn. After staging studies demonstrated no evidence of metastatic disease, radical excision with negative margins was performed. This case demonstrates that despite the rarity of radiation injury, each incidence necessitates strict monitoring of radiation exposure and continual follow-up due to the risk of malignancy.

摘要

普通冠状动脉支架置入术的辐射暴露量因多种因素而异,但每位患者通常为6-11毫希沃特(相比之下背景辐射为3毫希沃特)。与所有使用辐射的手术一样,存在基因突变和发生恶性肿瘤的固有风险。在此,我们报告一例75岁男性病例,该患者在七年前因冠状动脉导管插入术时间过长且受到辐射灼伤后,背部出现外生性肿块。对该病变进行活检显示,肿块与源自辐射灼伤部位的未分化多形性肉瘤一致。在分期检查未发现转移疾病的证据后,进行了切缘阴性的根治性切除。该病例表明,尽管辐射损伤罕见,但由于存在恶性肿瘤风险,每次发生都需要严格监测辐射暴露并持续随访。

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Radiat Oncol. 2017 Jan 26;12(1):29. doi: 10.1186/s13014-017-0769-0.
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Radiation-associated neoplasia: clinical, pathological and genomic correlates.辐射相关肿瘤:临床、病理及基因组相关性
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Intrascrotal paratesticular malignant fibrous histiocytoma-a rare case and its management.
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Therapeutic radiation and the potential risk of second malignancies.治疗性辐射与潜在的第二恶性肿瘤风险。
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