Discoidin domain receptor 1 在癌症转移中的信号转导作用。
Signaling by discoidin domain receptor 1 in cancer metastasis.
机构信息
a Human Oncology and Pathogenesis Program , Memorial Sloan Kettering Cancer Center , New York , NY , USA.
b Weill Cornell Graduate School of Medical Sciences , Cornell University , New York , NY , USA.
出版信息
Cell Adh Migr. 2018;12(4):315-323. doi: 10.1080/19336918.2018.1520556. Epub 2018 Oct 13.
Abstract
Collagen is the most abundant component of tumor extracellular matrix (ECM). ECM collagens are known to directly interact with the tumor cells via cell surface receptor and play crucial role in tumor cell survival and promote tumor progression. Collagen receptor DDR1 is a member of receptor tyrosine kinase (RTK) family with a unique motif in the extracellular domain resembling Dictyostelium discoideum protein discoidin-I. DDR1 displays delayed and sustained activation upon interaction with collagen and recent findings have demonstrated that DDR1-collagen signaling play important role in cancer progression. In this review, we discuss the current knowledge on the role of DDR1 in cancer metastasis and possibility of a potential therapeutic approach of DDR1 targeted therapy in cancer.
摘要
胶原蛋白是肿瘤细胞外基质（ECM）中最丰富的成分。已知 ECM 胶原蛋白可通过细胞表面受体与肿瘤细胞直接相互作用，并在肿瘤细胞存活和促进肿瘤进展中发挥关键作用。胶原蛋白受体 DDR1 是受体酪氨酸激酶（RTK）家族的成员，其细胞外结构域中存在一个独特的基序，类似于盘基网柄菌蛋白盘菌素-I。DDR1 在与胶原蛋白相互作用时表现出延迟和持续的激活，最近的研究结果表明，DDR1-胶原蛋白信号在癌症进展中发挥重要作用。在这篇综述中，我们讨论了 DDR1 在癌症转移中的作用的最新知识，并探讨了针对 DDR1 的潜在治疗方法在癌症治疗中的可能性。
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本文引用的文献
1
Cancer stem cell in breast cancer therapeutic resistance.
Cancer Treat Rev. 2018 Sep;69:152-163. doi: 10.1016/j.ctrv.2018.07.004. Epub 2018 Jul 18.
2
Cartilage oligomeric matrix protein: COMPopathies and beyond.
Matrix Biol. 2018 Oct;71-72:161-173. doi: 10.1016/j.matbio.2018.02.023. Epub 2018 Mar 9.
3
Receptor tyrosine kinases (RTKs) in breast cancer: signaling, therapeutic implications and challenges.
Mol Cancer. 2018 Feb 19;17(1):34. doi: 10.1186/s12943-018-0797-x.
4
Inhibition of DDR1-BCR signalling by nilotinib as a new therapeutic strategy for metastatic colorectal cancer.
EMBO Mol Med. 2018 Apr;10(4). doi: 10.15252/emmm.201707918.
5
Collagen I promotes hepatocellular carcinoma cell proliferation by regulating integrin β1/FAK signaling pathway in nonalcoholic fatty liver.
Oncotarget. 2017 Oct 5;8(56):95586-95595. doi: 10.18632/oncotarget.21525. eCollection 2017 Nov 10.
6
Metastases of malignant neoplasms: Historical, biological, & clinical considerations.
Semin Diagn Pathol. 2018 Mar;35(2):112-122. doi: 10.1053/j.semdp.2017.11.009. Epub 2017 Nov 24.
7
Feedback regulation of RTK signaling in development.
Dev Biol. 2019 Mar 1;447(1):71-89. doi: 10.1016/j.ydbio.2017.10.017. Epub 2017 Oct 26.
8
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Mol Cancer Ther. 2017 Nov;16(11):2473-2485. doi: 10.1158/1535-7163.MCT-16-0834. Epub 2017 Sep 1.
9
Surviving at a Distance: Organ-Specific Metastasis.
Trends Cancer. 2015 Sep;1(1):76-91. doi: 10.1016/j.trecan.2015.07.009. Epub 2015 Sep 28.
10
Collagen induces activation of DDR1 through lateral dimer association and phosphorylation between dimers.
Elife. 2017 Jun 7;6:e25716. doi: 10.7554/eLife.25716.
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