肠系膜作为肠道再生的中心。
The mesentery as the epicenter for intestinal regeneration.
机构信息
Biology Department, University of Puerto Rico, Puerto Rico.
出版信息
Semin Cell Dev Biol. 2019 Aug;92:45-54. doi: 10.1016/j.semcdb.2018.09.001. Epub 2018 Sep 6.
Abstract
The mesentery, a newly minted organ, plays various anatomical and physiological roles during animal development. In echinoderms, and particularly in members of the class Holothuroidea (sea cucumbers) the mesentery plays an additional unique role: it is crucial for the process of intestinal regeneration. In these organisms, a complete intestine can form from cells that originate in the mesentery. In this review, we focus on what is known about the changes that take place in the mesentery and what has been documented on the cellular and molecular mechanisms involved. We describe how the events that unfold in the mesentery result in the formation of a new intestine.
摘要
肠系膜，一个新出现的器官，在动物发育过程中发挥着各种解剖和生理作用。在棘皮动物中，特别是在海参纲（海参）成员中，肠系膜发挥着额外的独特作用：它对肠道再生过程至关重要。在这些生物体中，完整的肠道可以由起源于肠系膜的细胞形成。在这篇综述中，我们重点介绍肠系膜发生的变化以及有关细胞和分子机制的已有记录。我们描述了肠系膜中展开的事件如何导致新肠道的形成。
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