格林-巴利综合征的全基因组关联研究。
Genome-wide association study in Guillain-Barré syndrome.
机构信息
The University of Queensland, UQ Centre for Clinical Research, Royal Brisbane & Women's Hospital, Brisbane, Australia.
Translational Genomics Group, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology (QUT) at Translational Research Institute, Brisbane, Australia; Department of Neurology, Peking University Third Hospital, Beijing, PR China.
出版信息
J Neuroimmunol. 2018 Oct 15;323:109-114. doi: 10.1016/j.jneuroim.2018.07.016. Epub 2018 Aug 2.
Guillain-Barré syndrome (GBS) is considered to have an immune-mediated basis, but the genetic contribution to GBS is unclear. We conducted a GWAS involving 215 GBS patients and 1,105 healthy controls. No significant associations of individual SNPs or imputed HLA types were observed. We performed a genome-wide complex trait analysis for evaluation of the heritability of GBS, and found that common SNPs contribute up to 25% of susceptibility to the disease. Genetic risk score analysis showed no evidence of overlap in genetic susceptibility factors of GBS and multiple sclerosis. Given the unexplained heritability of the trait further larger GWAS are indicated.
格林-巴利综合征（GBS）被认为具有免疫介导的基础，但遗传因素在 GBS 中的作用尚不清楚。我们进行了一项包含 215 名 GBS 患者和 1105 名健康对照的全基因组关联研究（GWAS）。没有观察到单个 SNP 或推断的 HLA 类型的显著关联。我们进行了全基因组复杂性状分析，以评估 GBS 的遗传率，发现常见的 SNP 可导致高达 25%的疾病易感性。遗传风险评分分析显示，GBS 和多发性硬化症的遗传易感性因素没有重叠的证据。鉴于该特征的遗传率无法解释，需要进一步进行更大规模的 GWAS。
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