Zestos Alexander G, Venton B Jill
Department of Chemistry, American University, Washington, D.C., 20016,
Department of Chemistry, University of Virginia, Charlottesville, VA 22904,
J Electrochem Soc. 2018;165(12):G3071-G3073. doi: 10.1149/2.0111812jes. Epub 2018 Jul 25.
Carbon nanotube (CNT) yarn and fiber-microelectrodes were developed for neurotransmitter detection using fast scan cyclic voltammetry (FSCV). Fibers were made by suspending CNTs in acid/surfactant and extruding into acetone/polyethyleneimine (PEI) and compared to a CNT yarn. They were FSCV frequency independent for dopamine up to 100 Hz. With faster frequencies, up to 500 Hz, high currents are maintained, which allows a 2 ms sampling rate for FSCV, compared to 100 ms. CNT fibers have rough surfaces which trap dopamine and dopamine-o-quinone (DOQ), creating more reversible CVs. CNT yarns and fibers are beneficial for high sensitivity, rapid measurements of neurotransmitters.
碳纳米管(CNT)纱线和纤维微电极被开发用于使用快速扫描循环伏安法(FSCV)检测神经递质。通过将碳纳米管悬浮在酸/表面活性剂中并挤出到丙酮/聚乙烯亚胺(PEI)中来制备纤维,并与碳纳米管纱线进行比较。对于高达100 Hz的多巴胺,它们的FSCV频率无关。在高达500 Hz的更快频率下,能够维持高电流,这使得FSCV的采样率为2 ms,而相比之下为100 ms。碳纳米管纤维具有粗糙的表面,可捕获多巴胺和多巴胺邻醌(DOQ),从而产生更可逆的循环伏安图。碳纳米管纱线和纤维有利于高灵敏度、快速测量神经递质。