服用他莫昔芬的绝经后女性子宫内膜的宫腔镜检查与组织学检查的对比研究
Comparative Study on Hysteroscopic and Histologic Examinations of the Endometrium in Postmenopausal Women Taking Tamoxifen.
作者信息
Jung Hyuk, Jung Joo Kyoung, Kim Sat Byul, Cho Eun A, Um Mi Jung
机构信息
Department of Obstetrics and Gynecology, Chosun University College of Medicine, Gwangju, Korea.
Department of Obstetrics and Gynecology, Chosun University Hospital, Gwangju, Korea.
出版信息
J Menopausal Med. 2018 Aug;24(2):81-86. doi: 10.6118/jmm.2018.24.2.81. Epub 2018 Aug 31.
OBJECTIVES
To evaluate the histologic effects of tamoxifen on the endometrium using hysteroscopy in postmenopausal women with breast cancer.
METHODS
The study included 46 postmenopausal patients who were referred from another clinic due to thickening or bleeding of the endometrium after taking tamoxifen for breast cancer. All patients underwent transvaginal sonography (TVS) and hysteroscopic endometrial biopsy with a 5-mm, continuous-flow, operating hysteroscope.
RESULTS
The incidence of malignancy was high (20%) in cases of abnormal uterine bleeding (AUB) after taking tamoxifen. However, in the non-AUB group with thick endometrium after taking tamoxifen, the incidence of adenocarcinoma was 3.2%.
CONCLUSIONS
Our findings confirm the estrogen-like effect of tamoxifen on the endometrium. Endometrial evaluation with TVS suggests further diagnostic procedures; moreover, histologic examination is necessary under hysteroscopy, especially in cases of endometrial bleeding after taking tamoxifen.
目的
使用宫腔镜评估他莫昔芬对绝经后乳腺癌女性子宫内膜的组织学影响。
方法
该研究纳入了46名绝经后患者，她们因服用他莫昔芬治疗乳腺癌后出现子宫内膜增厚或出血而从另一诊所转诊而来。所有患者均接受了经阴道超声检查（TVS）以及使用5毫米连续灌流手术宫腔镜进行的宫腔镜子宫内膜活检。
结果
服用他莫昔芬后出现子宫异常出血（AUB）的病例中恶性肿瘤发生率较高（20%）。然而，在服用他莫昔芬后子宫内膜增厚的非AUB组中，腺癌发生率为3.2%。
结论
我们的研究结果证实了他莫昔芬对子宫内膜的雌激素样作用。TVS进行的子宫内膜评估提示需要进一步的诊断程序；此外，宫腔镜检查下的组织学检查是必要的，尤其是在服用他莫昔芬后出现子宫内膜出血的情况下。
Zotero 插件