Shimakura Hidekatsu, Dong Jianbao, Zhu Wei, Chambers James K, Uchida Kazuyuki, Kiriki Kensuke, Uematsu Mizuho, Goto Yoshitaka, Yasuda Masahiro, Yamashita-Kawanishi Nanako, Tsuzuki Masano, LE Dung T, Hatama Shinichi, Haga Takeshi
Division of Infection Control and Disease Prevention, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-Ku, Tokyo 113-8657, Japan.
Shandong Vocational Animal Science and Veterinary College, 88 Shenglidong Street, Weifang 261061, China.
J Vet Med Sci. 2018 Nov 9;80(11):1691-1695. doi: 10.1292/jvms.18-0289. Epub 2018 Sep 12.
Severe papillomatosis occasionally causes astasia leading to euthanizing cattle. There are currently a limited number of reports on virologic approach in severe bovine papillomatosis. Here we report a full genome characterization of bovine papillomavirus type 1 (BPV-1) from the case of severe papillomatosis. A calf developed numerous papillomas on the skin and some nodules in the upper gastrointestinal tract at seven months old. The skin lesion was diagnosed as the epithelial papilloma with BPV antigen expression, while the gastrointestinal lesions were diagnosed as the fibropapilloma without BPV antigen. Full genome analysis revealed that BPV-1s detected in all the lesions were exactly the same. Compared with the reference BPV-1 sequence, there was a single nucleotide insertion in the upstream regulatory region.
严重乳头瘤病偶尔会导致牛行动不能，从而不得不对牛实施安乐死。目前关于严重牛乳头瘤病病毒学方法的报道数量有限。在此，我们报告了一例严重乳头瘤病病例中牛乳头瘤病毒1型（BPV-1）的全基因组特征。一头小牛在7个月大时皮肤出现大量乳头瘤，上消化道出现一些结节。皮肤病变被诊断为具有BPV抗原表达的上皮乳头瘤，而胃肠道病变被诊断为无BPV抗原的纤维乳头瘤。全基因组分析显示，在所有病变中检测到的BPV-1完全相同。与参考BPV-1序列相比，上游调控区有一个单核苷酸插入。
