海洋来源放线菌 ZZ745 中新型的抗菌化合物 bagremycins F 和 G。
New Antibacterial Bagremycins F and G from the Marine-Derived sp. ZZ745.
机构信息
Ocean College, Zhoushan Campus, Zhejiang University, Zhoushan 316021, China.
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
出版信息
Mar Drugs. 2018 Sep 12;16(9):330. doi: 10.3390/md16090330.
As part of our research to discover novel bioactive natural products from marine microorganisms, five bagremycin analogues, including the previously unreported bagremycins F () and G (), were isolated from a marine actinomycete sp. ZZ745. The structures of these compounds were determined by means of NMR spectroscopic analysis, HRESIMS data, and optical rotation. Both bagremycins F () and G () showed antibacterial activity against , with MIC values of 41.8 and 61.7 μM, respectively.
作为我们从海洋微生物中发现新型生物活性天然产物的研究的一部分，从海洋放线菌 ZZ745 中分离到了五个 bagremycin 类似物，包括以前未报道过的 bagremycins F () 和 G ()。通过 NMR 波谱分析、HRESIMS 数据和旋光数据确定了这些化合物的结构。Bagremycins F () 和 G () 均显示出对 的抗菌活性，MIC 值分别为 41.8 和 61.7 μM。
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