果蝇多巴脱羧酶区域基因进化复制的证据。
Evidence for evolutionary duplication of genes in the dopa decarboxylase region of Drosophila.
作者信息
Eveleth D D, Marsh J L
出版信息
Genetics. 1986 Oct;114(2):469-83. doi: 10.1093/genetics/114.2.469.
Abstract
The region surrounding the dopa decarboxylase gene (Ddc) of Drosophila contains a cluster of genes, many of which appear to be functionally related by virtue of their effects on cuticle development and/or catecholamine metabolism. In this report we describe evidence that the Ddc gene and the closely linked alpha-methyldopa hypersensitive (amd) gene share extensive sequence homology and are the products of a gene duplication event. The two genes are transcribed convergently and are separated by 2.4 kb. A gene located between Ddc and amd expresses a 2.0-kb mRNA and appears to partially overlap the Ddc gene. The organization of these transcripts implies a complex series of events giving rise to the present pattern. The patterns of expression of these genes do not support a model of coordinate regulation, but are more consistent with a pattern of duplication and divergence to various related metabolic subspecialties. These data provide the first evidence for structural relationships among genes in the 37C cluster.
摘要
果蝇多巴脱羧酶基因（Ddc）周围的区域包含一组基因，其中许多基因似乎因其对表皮发育和/或儿茶酚胺代谢的影响而在功能上相关。在本报告中，我们描述了证据表明Ddc基因与紧密连锁的α-甲基多巴超敏（amd）基因具有广泛的序列同源性，并且是基因复制事件的产物。这两个基因反向转录，间隔2.4 kb。位于Ddc和amd之间的一个基因表达一种2.0 kb的mRNA，并且似乎与Ddc基因部分重叠。这些转录本的组织意味着产生当前模式的一系列复杂事件。这些基因的表达模式不支持协调调节模型，而是更符合向各种相关代谢亚专业的复制和分化模式。这些数据为37C簇中基因之间的结构关系提供了首个证据。
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