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胸主动脉腔内修复术后的住院时间取决于手术指征和病情严重程度。

Length of Stay after Thoracic Endovascular Aortic Repair Depends on Indication and Acuity.

作者信息

Belkin Nathan, Jackson Benjamin M, Foley Paul J, Damrauer Scott M, Kalapatapu Venkat, Golden Michael A, Fairman Ronald M, Kelz Rachel R, Wang Grace J

机构信息

Department of Vascular Surgery and Endovascular Therapy, Hospital of the University of Pennsylvania, Philadelphia, PA.

Department of Vascular Surgery and Endovascular Therapy, Hospital of the University of Pennsylvania, Philadelphia, PA.

出版信息

Ann Vasc Surg. 2019 Feb;55:157-165. doi: 10.1016/j.avsg.2018.06.027. Epub 2018 Sep 11.

Abstract

BACKGROUND

Length of stay (LOS) is a commonly used metric to optimize value in medical care. Although pathways have been developed for some procedures in vascular surgery to reduce LOS, they do not yet exist for thoracic endovascular aortic repair (TEVAR). The purpose of this study is to identify and define the risk factors for prolonged LOS in patients undergoing TEVAR to facilitate pathway development.

METHODS

We included TEVAR patients in the National Surgical Quality Improvement Program database from 2005 to 2015. Prolonged LOS was defined as LOS > 75th percentile of the overall cohort (11 days). Because initial analysis revealed the distinct clinical differences between dissection and aneurysm patients, further analysis was stratified by aortic pathology. Student's t-test and Chi-square tests were used to compare demographic and perioperative variables between dissection and aneurysm patients, respectively. Multivariable logistic regression was used to evaluate the predictors for prolonged LOS.

RESULTS

A total of 3,021 patients underwent TEVAR, with 858 patients (28.4%) undergoing TEVAR for dissection and 2,163 (71.6%) undergoing TEVAR for aneurysm. An initial analysis with logistic regression identified dissection indication (odds ratio [OR], 2.87; 95% confidence interval [CI], 1.1-7.3) as an independent predictor of prolonged LOS. Further analysis for prolonged LOS was subsequently performed separating dissection and aneurysm patients. Aneurysm patients were older (71.2 ± 11.7 vs. 63.1 ± 13.6 years, P < 0.001), more often Caucasian (76.8% vs. 61.8%, P < 0.001), and had more medical comorbidities (chronic obstructive pulmonary disease, cardiac history, diabetes, peripheral vascular disease, transient ischemic attack [TIA], P < 0.001). In contrast, dissection patients had higher American Society of Anesthesiology (ASA) classification score (58.5% had >3 ASA vs. 45.5%, P < 0.001), longer hospitalizations (10.2 ± 9.3 vs. 8.5 ± 10.4 days, P < 0.001), were more likely to have been transferred from another hospital or emergency room (58.4% vs. 48.3%, P < 0.001), and were more often emergent (32.4% vs. 15.4%, P < 0.001). In dissection patients, ASA classification score (OR, 1.49; 95% CI, 1.1-2.1) and dialysis (OR, 1.98; 95% CI, 1.0-3.9) were independent predictors for prolonged LOS. In aneurysm patients, dependent functional status (OR, 2.03; 95% CI, 1.4-2.8), diabetes (OR, 1.75; 95% CI, 1.1-2.8), cardiac history (OR, 1.37; 95% CI, 1.0-1.9), emergency status (OR, 1.98; 95% CI, 1.4-2.8), and dialysis (OR, 2.08; 95% CI, 1.2-3.7) predicted prolonged LOS. Postoperative complications including stroke/TIA; failure to wean from ventilator, sepsis, and pneumonia; and need for reoperation similarly increased LOS in both dissection and aneurysm patients.

CONCLUSIONS

Dissection and aneurysm patients undergoing TEVAR are comprised of different patient populations, with dissection patients more often enduring prolonged hospitalizations. In contrast, TEVAR performed for nonemergent aneurysm repair had the shortest LOS. These data support the development of separate pathways defined by indication and acuity for patients undergoing TEVAR.

摘要

背景

住院时间(LOS)是优化医疗价值时常用的指标。尽管已经为血管外科的某些手术制定了减少住院时间的路径,但胸主动脉腔内修复术(TEVAR)尚无此类路径。本研究的目的是识别并确定接受TEVAR治疗的患者住院时间延长的风险因素,以促进路径的制定。

方法

我们纳入了2005年至2015年国家外科质量改进计划数据库中的TEVAR患者。住院时间延长定义为超过整个队列第75百分位数的住院时间(11天)。由于初步分析显示夹层和动脉瘤患者之间存在明显的临床差异,因此进一步分析按主动脉病变进行分层。分别采用学生t检验和卡方检验比较夹层和动脉瘤患者的人口统计学和围手术期变量。多变量逻辑回归用于评估住院时间延长的预测因素。

结果

共有3021例患者接受了TEVAR治疗,其中858例(28.4%)因夹层接受TEVAR治疗,2163例(71.6%)因动脉瘤接受TEVAR治疗。逻辑回归的初步分析确定夹层指征(比值比[OR],2.87;95%置信区间[CI],1.1 - 7.3)是住院时间延长的独立预测因素。随后对夹层和动脉瘤患者分别进行了住院时间延长的进一步分析。动脉瘤患者年龄较大(71.2±11.7岁 vs. 63.1±13.6岁,P<0.001),白人比例更高(76.8% vs. 61.8%,P<0.001),且有更多的内科合并症(慢性阻塞性肺疾病、心脏病史、糖尿病、外周血管疾病、短暂性脑缺血发作[TIA],P<0.001)。相比之下,夹层患者美国麻醉医师协会(ASA)分级评分更高(58.5%的患者ASA>3级 vs. 45.5%,P<0.001),住院时间更长(10.2±9.3天 vs. 8.5±10.4天,P<0.001),更有可能是从另一家医院或急诊室转诊而来(58.4% vs. 48.3%,P<0.001),且急诊情况更常见(32.4% vs. 15.4%,P<0.001)。在夹层患者中,ASA分级评分(OR,1.49;95%CI,1.1 - 2.1)和透析(OR,1.98;95%CI,1.0 - 3.9)是住院时间延长的独立预测因素。在动脉瘤患者中,依赖性功能状态(OR,2.03;95%CI,1.4 - 2.8)、糖尿病(OR,1.75;95%CI,1.1 - 2.8)、心脏病史(OR,1.37;95%CI,1.0 - 1.9)、急诊状态(OR,1.98;95%CI,1.4 - 2.8)和透析(OR,2.08;95%CI,1.2 - 3.7)可预测住院时间延长。术后并发症包括中风/TIA;脱机失败、败血症和肺炎;以及再次手术需求同样会增加夹层和动脉瘤患者的住院时间。

结论

接受TEVAR治疗的夹层和动脉瘤患者群体不同,夹层患者住院时间更长。相比之下,非急诊动脉瘤修复的TEVAR住院时间最短。这些数据支持为接受TEVAR治疗的患者制定根据指征和病情严重程度区分的不同路径。

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