从真菌 sp. 中分离得到的吲哚二萜及其抗菌活性。
An indole diterpenoid isolated from the fungus sp. and its antimicrobial activity.
机构信息
a College of Pharmacy, College (Institute) of Integrative Medicine, The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease, Dalian Medical University , Dalian , China.
b School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University , Shenyang , China.
出版信息
Nat Prod Res. 2019 Oct;33(19):2770-2776. doi: 10.1080/14786419.2018.1501050. Epub 2018 Sep 17.
One new indole diterpenoid, drechmerin I (), was isolated from the fermentation broth of sp. isolated from the root of . Its structure was elucidated based on 1 D and 2 D nuclear magnetic resonance (NMR), high resolution electrospray ionization mass spectrum (HRESIMS), and electronic circular dichroism (ECD) spectroscopic analyses as well as TD DFT calculations of ECD spectra. Drechmerin I () was assayed for its antimicrobial activity against , , , , , and , respectively. Drechmerin I () showed antimicrobial activities against with an MIC value of 200 μg/mL. The interaction of peptide deformylase with drechmerin I () was investigated by molecular docking.
从 sp. 的发酵液中分离得到一种新的吲哚二萜，命名为 drechmerin I ()。根据 1D 和 2D 核磁共振 (NMR)、高分辨电喷雾电离质谱 (HRESIMS) 和电子圆二色 (ECD) 光谱分析以及 ECD 光谱的 TD DFT 计算，确定了其结构。对 drechmerin I () 进行了抗微生物活性测试，分别针对 、 、 、 、 和 。Drechmerin I () 对 具有抗微生物活性，MIC 值为 200 μg/mL。通过分子对接研究了肽脱甲酰酶与 drechmerin I () 的相互作用。
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