恒河猴（猕猴）口腔及黏膜引流淋巴结中自然杀伤细胞的间接激活
Indirect activation of rhesus macaque (Macaca mulatta) NK cells in oral and mucosal draining lymph nodes.
作者信息
Ram Daniel R, Kroll Kyle, Reeves R Keith
机构信息
Harvard Medical School, Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, Massachusetts.
出版信息
J Med Primatol. 2018 Oct;47(5):302-304. doi: 10.1111/jmp.12371. Epub 2018 Sep 6.
Abstract
The oral mucosae and draining lymph nodes are primary entry points for invading pathogens, particularly during immunosuppressive HIV/SIV infections. Innate immunity against oral stimuli, including natural killer (NK) cells, is understudied. Herein, we demonstrate functional NK cell responses to pathogen-associated molecular patterns (PAMPs) of potential oral pathogens in rhesus macaques.
摘要
口腔黏膜和引流淋巴结是入侵病原体的主要入口，尤其是在免疫抑制性HIV/SIV感染期间。针对包括自然杀伤（NK）细胞在内的口腔刺激的固有免疫研究不足。在此，我们展示了恒河猴中NK细胞对潜在口腔病原体的病原体相关分子模式（PAMP）的功能性反应。
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