Department of Oncology, McGill University Health Centre, Montreal, Quebec, Canada
Department of Medicine, Cedars Cancer Centre, McGill University Health Centre, Montreal, Quebec, Canada.
Oncologist. 2019 Mar;24(3):e111-e114. doi: 10.1634/theoncologist.2018-0081. Epub 2018 Sep 26.
Little has been published about the association of venous thromboembolism (VTE) and sarcoma. In this study, we sought to identify clinical features of patients with sarcoma presenting at least one VTE episode.
Our study was a retrospective case-control study of a single-institution database with univariate and multivariate analysis using chi-square and Student's test. A value less than .05 was considered significant.
The overall incidence of VTE in patients with sarcoma was 7.9%. Predictive factors identified by multivariate analysis were metastatic disease and administration of chemotherapy. It was not statistically possible to correlate the risk of VTE with specific sarcoma subtypes, but observations suggested malignant peripheral nerve sheath tumor, osteosarcoma, and liposarcoma as having the highest propension.
VTE is not infrequent in patients with sarcoma. Adoption of common guidelines for cancer-associated thrombosis is recommended.
静脉血栓栓塞症(VTE)和肉瘤之间的关联鲜有报道。在这项研究中,我们试图确定至少出现一次 VTE 发作的肉瘤患者的临床特征。
这是一项单中心数据库的回顾性病例对照研究,采用卡方检验和学生 t 检验进行单变量和多变量分析。 值小于.05 被认为具有统计学意义。
肉瘤患者 VTE 的总体发生率为 7.9%。多变量分析确定的预测因素是转移性疾病和化疗的应用。虽然无法从统计学上确定 VTE 风险与特定的肉瘤亚型之间的相关性,但观察结果表明恶性外周神经鞘瘤、骨肉瘤和脂肪肉瘤的倾向最高。
VTE 在肉瘤患者中并不罕见。建议采用常见的癌症相关性血栓形成指南。