海洋放线菌 Streptomyces 中具有罕见的 6/5/5 三环骨架的链甘油酯 A-D
Streptoglycerides A-D with a Rare 6/5/5 Tricyclic Ring Skeleton from a Marine Actinomycete Streptomyces species.
机构信息
Department of Marine Biotechnology , Korea University of Science and Technology , Daejeon 34113 , Republic of Korea.
Marine Natural Products Chemistry Laboratory , Korea Institute of Ocean Science and Technology , 385 Haeyang-ro, Yeongdo-gu , Busan 49111 , Republic of Korea.
出版信息
Org Lett. 2018 Oct 5;20(19):6037-6040. doi: 10.1021/acs.orglett.8b02411. Epub 2018 Sep 27.
Four novel secondary metabolites possessing a unique 6/5/5 tricyclic ring system, streptoglycerides A-D (1-4), were isolated from a marine actinomycete Streptomyces sp. derived from a mangrove sample collected on Kosrae Island. Their structures and absolute configurations were elucidated by spectroscopic data and electronic circular dichroism data. Streptoglyceride C (3) showed a weak inhibitory effect on the production of nitric oxide in BV-2 microglia cells.
从科斯拉尔岛采集的红树林样本中分离到的海洋放线菌链霉菌属中分离得到了四个新型次生代谢产物 1-4，它们均具有独特的 6/5/5 三环体系。通过光谱数据和电子圆二色性数据阐明了它们的结构和绝对构型。 链霉菌甘油酯 C（3）对 BV-2 小胶质细胞中一氧化氮的产生具有较弱的抑制作用。
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