Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, CA, USA.
Division of Gastroenterology and Hepatology, Alameda Health System, Highland Hospital, Oakland, CA, USA.
Dig Dis Sci. 2018 Dec;63(12):3250-3252. doi: 10.1007/s10620-018-5316-9.
The availability of the new generation of direct-acting antiviral (DAA) therapies for the treatment of chronic hepatitis C virus (HCV) infection has completely transformed the HCV therapeutic landscape. Current regimens provide pan-genotypic coverage that are of short duration, safer, and are highly effective than prior generations of HCV therapeutics. While data from clinical trials and real-world experience continue to demonstrate similar and high sustained virologic response (SVR) rates, the successful implementation of the HCV cascade-of-care including screening, confirmation of active infection, treatment initiation and successful completion of therapy among more challenging populations, such as the underserved populations who are also disproportionally affected by HCV, remains vital to HCV eradication efforts.
新一代直接作用抗病毒(DAA)药物的出现彻底改变了慢性丙型肝炎病毒(HCV)感染的治疗格局。目前的治疗方案具有广泛的基因型覆盖,疗程更短、安全性更高,并且比以往几代 HCV 治疗药物更有效。虽然临床试验和真实世界经验的数据继续显示出相似的高持续病毒学应答(SVR)率,但成功实施 HCV 护理链,包括在更具挑战性的人群中进行筛查、确认活动性感染、开始治疗和成功完成治疗,对于 HCV 消除工作仍然至关重要,这些人群包括服务不足的人群,他们也不成比例地受到 HCV 的影响。