α1-抗胰蛋白酶对人血清总抗胰蛋白酶活性的贡献。对两名PI OO表型个体的研究。

The contribution of alpha1-antitrypsin to the total antitrypsin activity of human serum. A study of two phenotype PI OO individuals.

作者信息

Kahn M J, Schandevijl W, Philipi G, Frank H L

出版信息

Clin Chim Acta. 1977 Nov 1;80(3):513-8. doi: 10.1016/0009-8981(77)90145-0.

Abstract

Comparison of the levels of alpha1-AT, alpha2-M, inter alpha-AT, C1 inactivator and antiplasmin and global antitrypsin activity in a group of normal phenotype PI MM individuals, a group of normal individuals with phenotypes with intermediate alpha1 AT activities and alpha2-AT-deficient persons show that alpha1-AT contributes more than 90 percent of the total antitrypsin activity of normal plasma. AT III and fast reacting antiplasmin are shown to contribute to the remaining activity. It can be assumed that due to test conditions the antitrypsin activity of alpha2-M is not assessed. C1 inactivator and inter alpha1-AT do not contribute to a perceptible extent to the overall antitrypsin activity estimated according to the method of Eriksson (Eriksson, S. (1965) Acta Med. Scand. 177, 1).

摘要

对一组正常表型PI MM个体、一组具有中等α1抗胰蛋白酶活性表型的正常个体以及α2抗胰蛋白酶缺乏者的α1抗胰蛋白酶（α1-AT）、α2巨球蛋白（α2-M）、α1抗胰蛋白酶中间物（inter alpha-AT）、C1灭活剂和抗纤溶酶水平以及总抗胰蛋白酶活性进行比较，结果表明α1-AT在正常血浆的总抗胰蛋白酶活性中所占比例超过90%。已证明抗凝血酶III（AT III）和快速反应抗纤溶酶对其余活性有贡献。可以假定，由于测试条件，未评估α2-M的抗胰蛋白酶活性。根据Eriksson的方法（Eriksson, S. (1965) Acta Med. Scand. 177, 1）估算，C1灭活剂和α1抗胰蛋白酶中间物对总体抗胰蛋白酶活性的贡献不明显。