Suppr超能文献

父母身份对已婚个体中酒精使用障碍登记风险的影响:一项基于瑞典人群的分析。

The impact of parenthood on risk of registration for alcohol use disorder in married individuals: a Swedish population-based analysis.

机构信息

Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.

Department of Psychiatry, Virginia Commonwealth University, Richmond VA, USA.

出版信息

Psychol Med. 2019 Oct;49(13):2141-2148. doi: 10.1017/S0033291718002969. Epub 2018 Oct 25.

Abstract

BACKGROUND

Although being married with children is associated with a reduced rate of alcohol use disorder (AUD), is this finding independent of a marital effect, different in mothers and fathers and potentially causal in effect.

METHODS

Using Cox proportional hazards, we examined, in 1 252 237 married individuals, the association between a resident younger and older child and risk for AUD registration in national medical, criminal, and pharmacy registers. Using logistic regression, we analyzed, in 600 219 parents, within-person models comparing risk for AUD prior to first pregnancy v. with young children. We examined whether risk for AUD in 1302 parents after a first spousal AUD registration was reduced by having a young resident child.

RESULTS

Compared with childless married individuals, resident younger children were associated with a reduced risk for AUD in mothers [hazard ratio (HR) 0.36, 95% confidence interval 0.31-0.41] and fathers (HR 0.66, 0.60-0.73). The reduced risk was attenuated but still significant for older children. Within-person models confirmed the protective effect of young children in mothers [odds ratio (OR) 0.49, 0.30-0.80] but yielded inconclusive results in fathers (OR 0.85, 0.58-1.25). After a first spousal registration for AUD, a resident young child was associated with a substantial reduction in risk for mothers and a weaker marginal effect in fathers.

CONCLUSION

In married individuals, resident children are associated with a reduction in basal risk for AUD which is stronger in mothers than fathers and with younger v. older children. This effect is also evident during high-risk periods. In mothers, our results are consistent with a largely causal effect.

摘要

背景

尽管已婚并有子女与较低的酒精使用障碍(AUD)发生率相关,但这种关联是否独立于婚姻因素,在母亲和父亲中是否存在差异,以及是否具有因果效应。

方法

使用 Cox 比例风险模型,我们在 1252237 名已婚个体中,检查了年幼和年长子女的居住情况与国家医疗、刑事和药房登记处 AUD 登记风险之间的关联。使用逻辑回归,我们在 600219 名父母中,分析了在首次怀孕前与有年幼子女时相比 AUD 风险的个体内模型。我们研究了在首次配偶 AUD 登记后,有年幼的常住子女是否会降低 1302 名父母的 AUD 风险。

结果

与无子女的已婚个体相比,年幼的常住子女与母亲(危险比 [HR] 0.36,95%置信区间 0.31-0.41)和父亲(HR 0.66,0.60-0.73)的 AUD 风险降低相关。对于年长子女,风险降低虽然减弱但仍然具有统计学意义。个体内模型证实了年幼子女对母亲的保护作用(优势比 [OR] 0.49,0.30-0.80),但在父亲中结果不确定(OR 0.85,0.58-1.25)。在首次配偶 AUD 登记后,有年幼的常住子女与母亲 AUD 风险的大幅降低相关,而对父亲的边际效应较弱。

结论

在已婚个体中,常住子女与 AUD 的基础风险降低相关,这种关联在母亲中比父亲中更强,与年幼子女相比与年长子女相关。这种效应在高风险时期也存在。在母亲中,我们的结果与因果效应一致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/608a/6483884/c0b800c458f6/nihms-996315-f0001.jpg

相似文献

3
The Origin of Spousal Resemblance for Alcohol Use Disorder.酒精使用障碍的配偶相似性起源。
JAMA Psychiatry. 2018 Mar 1;75(3):280-286. doi: 10.1001/jamapsychiatry.2017.4457.

引用本文的文献

2
Household Compositions and Substance Use among Young Adults in the U.S.美国家庭构成与年轻人的物质使用情况
Int J Environ Res Public Health. 2024 Aug 14;21(8):1067. doi: 10.3390/ijerph21081067.

本文引用的文献

1
The Origin of Spousal Resemblance for Alcohol Use Disorder.酒精使用障碍的配偶相似性起源。
JAMA Psychiatry. 2018 Mar 1;75(3):280-286. doi: 10.1001/jamapsychiatry.2017.4457.
4
Neurobiology of addiction: a neurocircuitry analysis.成瘾的神经生物学:神经回路分析
Lancet Psychiatry. 2016 Aug;3(8):760-773. doi: 10.1016/S2215-0366(16)00104-8.

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验