Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Department of Psychiatry, Virginia Commonwealth University, Richmond VA, USA.
Psychol Med. 2019 Oct;49(13):2141-2148. doi: 10.1017/S0033291718002969. Epub 2018 Oct 25.
Although being married with children is associated with a reduced rate of alcohol use disorder (AUD), is this finding independent of a marital effect, different in mothers and fathers and potentially causal in effect.
Using Cox proportional hazards, we examined, in 1 252 237 married individuals, the association between a resident younger and older child and risk for AUD registration in national medical, criminal, and pharmacy registers. Using logistic regression, we analyzed, in 600 219 parents, within-person models comparing risk for AUD prior to first pregnancy v. with young children. We examined whether risk for AUD in 1302 parents after a first spousal AUD registration was reduced by having a young resident child.
Compared with childless married individuals, resident younger children were associated with a reduced risk for AUD in mothers [hazard ratio (HR) 0.36, 95% confidence interval 0.31-0.41] and fathers (HR 0.66, 0.60-0.73). The reduced risk was attenuated but still significant for older children. Within-person models confirmed the protective effect of young children in mothers [odds ratio (OR) 0.49, 0.30-0.80] but yielded inconclusive results in fathers (OR 0.85, 0.58-1.25). After a first spousal registration for AUD, a resident young child was associated with a substantial reduction in risk for mothers and a weaker marginal effect in fathers.
In married individuals, resident children are associated with a reduction in basal risk for AUD which is stronger in mothers than fathers and with younger v. older children. This effect is also evident during high-risk periods. In mothers, our results are consistent with a largely causal effect.
尽管已婚并有子女与较低的酒精使用障碍(AUD)发生率相关,但这种关联是否独立于婚姻因素,在母亲和父亲中是否存在差异,以及是否具有因果效应。
使用 Cox 比例风险模型,我们在 1252237 名已婚个体中,检查了年幼和年长子女的居住情况与国家医疗、刑事和药房登记处 AUD 登记风险之间的关联。使用逻辑回归,我们在 600219 名父母中,分析了在首次怀孕前与有年幼子女时相比 AUD 风险的个体内模型。我们研究了在首次配偶 AUD 登记后,有年幼的常住子女是否会降低 1302 名父母的 AUD 风险。
与无子女的已婚个体相比,年幼的常住子女与母亲(危险比 [HR] 0.36,95%置信区间 0.31-0.41)和父亲(HR 0.66,0.60-0.73)的 AUD 风险降低相关。对于年长子女,风险降低虽然减弱但仍然具有统计学意义。个体内模型证实了年幼子女对母亲的保护作用(优势比 [OR] 0.49,0.30-0.80),但在父亲中结果不确定(OR 0.85,0.58-1.25)。在首次配偶 AUD 登记后,有年幼的常住子女与母亲 AUD 风险的大幅降低相关,而对父亲的边际效应较弱。
在已婚个体中,常住子女与 AUD 的基础风险降低相关,这种关联在母亲中比父亲中更强,与年幼子女相比与年长子女相关。这种效应在高风险时期也存在。在母亲中,我们的结果与因果效应一致。