对从韩国猪中分离出的携带耐黏菌素mcr-3基因的p17S - 208质粒进行的遗传分析。
Genetic Analysis of p17S-208 Plasmid Encoding the Colistin Resistance mcr-3 Gene in Escherichia coli Isolated from Swine in South Korea.
作者信息
Belaynehe Kuastros Mekonnen, Shin Seung Won, Park Kyung Yoon, Jang Ji Young, Won Ho Geun, Yoon In Joong, Yoo Han Sang
机构信息
1 Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University , Seoul, Republic of Korea.
2 Research Unit, Green Cross Veterinary Products , Yongin, Republic of Korea.
出版信息
Microb Drug Resist. 2019 Apr;25(3):457-461. doi: 10.1089/mdr.2018.0132. Epub 2018 Oct 31.
We screened, for the first time, plasmid-mediated colistin resistance mcr-3 genes among 636 Escherichia coli isolates collected from swine in South Korea. Whole-genome sequencing showed that the E. coli strain harbored the mcr-3 gene in a p17S-208 plasmid with an IncHI2-ST3 plasmid type and a size of 260,399 base pairs. The deduced amino acid sequences revealed that persistent evolution in the bacterial genome has resulted in mcr gene variants. There is a need for extensive surveillance to prevent the dissemination of colistin resistance mcr genes from animal to human.
我们首次在从韩国猪群中收集的636株大肠杆菌分离株中筛选了质粒介导的黏菌素耐药mcr-3基因。全基因组测序显示，该大肠杆菌菌株在一个大小为260,399碱基对、质粒类型为IncHI2-ST3的p17S-208质粒中携带mcr-3基因。推导的氨基酸序列表明，细菌基因组中的持续进化导致了mcr基因变体的产生。有必要进行广泛监测，以防止黏菌素耐药mcr基因从动物传播到人类。
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