From the Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan.
Department of Clinical Anesthesiology, Mie University Hospital, Mie, Japan.
Anesth Analg. 2019 Feb;128(2):213-220. doi: 10.1213/ANE.0000000000003888.
The effect of preoperative transthoracic echocardiography on the clinical outcomes of patients with hip fractures undergoing surgical treatment remains controversial. We hypothesized that preoperative echocardiography is associated with reduced postoperative morbidity and improved patient survival after surgical repair of hip fractures.
Drawing from a nationwide administrative database, patients undergoing hip fracture surgeries between April 1, 2008 and December 31, 2016 were included. We examined the association of preoperative echocardiography with the incidence of in-hospital mortality using propensity score matching. Secondary outcomes included postoperative complications, the incidence of postoperative intensive care unit admissions, and length of hospital stay. For sensitivity analyses, we restricted the overall cohort to include only hip fracture surgeries performed within 2 days from admission.
Overall, 34,679 (52.1%) of 66,620 surgical patients underwent preoperative echocardiography screening. The screened patients (mean [SD] age, 84.3 years [7.7 years]; 79.0% female) were propensity score matched to 31,941 nonscreened patients (mean [SD] age, 82.1 years [8.7 years]; 78.2% female). The overall in-hospital mortality, before propensity matching, was 1.8% (1227 patients). Propensity score matching created a matched cohort of 25,205 pairs of patients. There were no in-hospital mortality differences between the 2 groups (screened versus nonscreened: 417 [1.65%] vs 439 [1.74%]; odds ratio, 0.95; 95% confidence interval, 0.83-1.09; P = .45). Preoperative echocardiography was not associated with reduced postoperative complications and intensive care unit admissions. In sensitivity analysis, we identified 25,637 patients from the overall cohort (38.5%) with hip fracture surgeries performed within 2 days of admission. There were no in-hospital mortality differences between the 2 groups (screened versus nonscreened: 1.67% vs 1.80%; odds ratio, 0.93; 95% confidence interval, 0.72-1.18; P = .53). Findings were also consistent with other sensitivity analyses and subgroup analyses.
This large, retrospective, nationwide cohort study demonstrated that preoperative echocardiography was not associated with reduced in-hospital mortality or postoperative complications.
术前经胸超声心动图对接受手术治疗的髋部骨折患者的临床结局的影响仍存在争议。我们假设术前超声心动图与髋部骨折手术后的术后发病率降低和患者生存率提高有关。
从全国性行政数据库中,选取 2008 年 4 月 1 日至 2016 年 12 月 31 日期间接受髋部骨折手术的患者。我们使用倾向评分匹配检查术前超声心动图与住院内死亡率之间的关联。次要结局包括术后并发症、术后入住重症监护病房的发生率和住院时间。对于敏感性分析,我们将整个队列限制为仅包括从入院起 2 天内进行的髋部骨折手术。
总体而言,在 66620 例手术患者中,有 34679 例(52.1%)接受了术前超声心动图筛查。筛选出的患者(平均[标准差]年龄,84.3 岁[7.7 岁];79.0%为女性)与 31941 例未筛选出的患者(平均[标准差]年龄,82.1 岁[8.7 岁];78.2%为女性)进行了倾向评分匹配。在没有进行倾向评分匹配之前,总的院内死亡率为 1.8%(1227 例患者)。倾向评分匹配创建了一个匹配的 25205 对患者队列。两组之间的院内死亡率没有差异(筛查组与未筛查组:417[1.65%] vs 439[1.74%];比值比,0.95;95%置信区间,0.83-1.09;P=.45)。术前超声心动图与术后并发症和重症监护病房入住率的降低无关。在敏感性分析中,我们从整个队列中确定了 25637 例(38.5%)在入院后 2 天内进行髋部骨折手术的患者。两组之间的院内死亡率没有差异(筛查组与未筛查组:1.67% vs 1.80%;比值比,0.93;95%置信区间,0.72-1.18;P=.53)。研究结果与其他敏感性分析和亚组分析一致。
这项大型回顾性全国性队列研究表明,术前超声心动图与降低院内死亡率或术后并发症无关。