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影响中国 2-3 岁儿童常规免疫状况的因素。

Factors influencing the routine immunization status of children aged 2-3 years in China.

机构信息

National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing, China.

出版信息

PLoS One. 2018 Oct 31;13(10):e0206566. doi: 10.1371/journal.pone.0206566. eCollection 2018.

Abstract

OBJECTIVES

To examine the factors associated with the routine immunization status of children aged 2-3 years in China for gaining a better understanding of the Expanded Program on Immunization and to provide evidence for formulating specific strategies to guide the allocation of health resources.

METHODS

We analyzed data from 45095 children aged 2-3 years in the 2013 National Immunization Coverage Survey to identify the sociodemographic and provider-associated factors affecting the full immunization status of children. Univariate and multiple logistic regression analyses were performed.

RESULTS

The immunization rate for children aged 2-3 years ranged from 95.9% (diphtheria and tetanus toxoid with pertussis vaccine, 4th dose) to 99.5% (Japanese encephalitis vaccine, 1st dose) and was 93.1% for full immunization. In terms of sociodemographic factors, male children [adjusted OR (AOR): 1.115; 95% confidence interval(CI):1.016-1.222], minority children (AOR: 1.632; 95% CI: 1.457-1.828), children of fathers with less than high school education (AOR: 1.577; 95% CI: 1.195-2.081), those born at home (AOR: 4.655; 95% CI: 3.771-5.746), those who immigrated from an adjacent county (AOR: 2.006; 95% CI: 1.581-2.546), and those living in urban-rural fringe areas (AOR: 1.807; 95% CI: 1.475-2.214) or mountainous areas (AOR: 1.615; 95% CI: 1.437-1.814) had significantly increased odds of not being fully immunized. In terms of provider-associated factors, administration of vaccines at home (AOR: 2.311; 95% CI: 1.316-4.059), household reminders (AOR: 2.292; 95% CI: 1.884-2.789), and travel time to vaccination providers of >40 minutes (AOR: 1.622; 95% CI: 1.309-2.010) were negatively associated with immunization rates. In addition, compared to 3-year-old years, 2-year-old children (AOR: 1.201; 95% CI: 1.094-1.318) were less likely to be fully immunized.

CONCLUSIONS

All included factors except maternal education level and distance from home to vaccination providers significantly affected immunization rates. Appropriate reminders and accessibility of immunization services played key roles in improving the immunization status. More attention to high-risk groups identified in this study may reduce the disparities in routine childhood immunization in China.

摘要

目的

分析中国 2-3 岁儿童常规免疫状况的影响因素,了解扩大免疫规划实施情况,为合理配置卫生资源提供依据。

方法

利用 2013 年全国免疫规划监测数据,对 45095 名 2-3 岁儿童的社会人口学和服务提供相关因素进行分析,采用单因素和多因素 logistic 回归分析方法,探讨儿童常规免疫状况的影响因素。

结果

2-3 岁儿童各疫苗接种率为 95.9%(百白破疫苗第 4 剂)-99.5%(乙脑疫苗第 1 剂),全程接种率为 93.1%。社会人口学因素中,男孩(调整 OR:1.115,95%CI:1.016-1.222)、少数民族(调整 OR:1.632,95%CI:1.457-1.828)、父亲文化程度为小学及以下(调整 OR:1.577,95%CI:1.195-2.081)、在家出生(调整 OR:4.655,95%CI:3.771-5.746)、来自邻县(调整 OR:2.006,95%CI:1.581-2.546)、城乡结合部(调整 OR:1.807,95%CI:1.475-2.214)和山区(调整 OR:1.615,95%CI:1.437-1.814)儿童未全程接种的风险增加。服务提供相关因素中,家庭接种(调整 OR:2.311,95%CI:1.316-4.059)、家庭提醒(调整 OR:2.292,95%CI:1.884-2.789)和到接种点时间超过 40 min(调整 OR:1.622,95%CI:1.309-2.010)与儿童免疫率降低有关。此外,与 3 岁儿童相比,2 岁儿童(调整 OR:1.201,95%CI:1.094-1.318)未全程接种的风险降低。

结论

除母亲文化程度和居住地到接种点的距离外,其他所有因素均对儿童免疫率有显著影响。适当的提醒和便捷的接种服务在提高免疫率方面发挥着重要作用。本研究中确定的高危人群应给予更多关注,以减少中国儿童常规免疫的差异。

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