先进药物靶向治疗中的纳米结构系统：最新专利。
Nanostructured Systems in Advanced Drug Targeting for the Cancer Treatment: Recent Patents.
机构信息
Cell Biology Laboratory, Biomedical Research Center of the East, Mexican Institute of Social Security, Metepec, Puebla CP 74360, Mexico.
Department of Neuurosciences, National Institute of Rehabilitation, City of Mexico, Mexico.
出版信息
Recent Pat Anticancer Drug Discov. 2019;14(1):85-94. doi: 10.2174/1574892813666181031154146.
BACKGROUND
Cancer is one of the leading causes of death in the world and it is necessary to develop new strategies for its treatment because most therapies have limited access to many types of tumors, as well as low therapeutic efficacy and high toxicity.
OBJECTIVE
The present research aims to identify recent patents of drug delivery nanostructured systems that may have application in improving cancer treatment.
METHODS
Recent patents regarding the drug delivery nanostructured systems for cancer treatment were obtained from the patent databases of the six main patent offices of the world: United States Patent and Trademark Office, European Patent Office, World Intellectual Property Organization, Japan Patent Office, State Intellectual Property Office of China and Korean Intellectual Property Office.
RESULTS
A total of 1710 patent documents from 1998 to 2017 including "drug delivery nanostructured systems for cancer treatment" were retrieved. The top five countries in patent share were USA, China, South Korea, Canada and Germany. The universities and enterprises of USA had the highest amount of patents followed by institutions from China.
CONCLUSION
There is a strong tendency for the development of new nanostructured systems for the release of drugs; particularly, in recent years, the development of nanoparticles has focused on nanodiscs, gold nanoparticles and immunoliposomes.
背景
癌症是全球主要死因之一，因此有必要开发新的治疗策略，因为大多数疗法对许多类型的肿瘤的疗效有限，且疗效低、毒性高。
目的
本研究旨在确定用于改善癌症治疗的药物传递纳米结构系统的最新专利。
方法
从世界六个主要专利局（美国专利商标局、欧洲专利局、世界知识产权组织、日本专利局、中国国家知识产权局和韩国知识产权局）的专利数据库中获取了关于癌症治疗用药物传递纳米结构系统的最新专利。
结果
检索到了 1998 年至 2017 年期间共 1710 份包含“用于癌症治疗的药物传递纳米结构系统”的专利文献。专利份额排名前五的国家是美国、中国、韩国、加拿大和德国。美国的大学和企业拥有最多的专利，其次是来自中国的机构。
结论
开发用于药物释放的新型纳米结构系统的趋势很强；特别是近年来，纳米盘、金纳米粒子和免疫脂质体等纳米粒子的开发成为了重点。
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