伴有脑转移的嗜铬细胞瘤：全球极为罕见的病例

Pheochromocytoma with Brain Metastasis: A Extremely Rare Case in Worldwide.

作者信息

Cho Yun Seong, Ryu Hyang Joo, Kim Se Hoon, Kang Seok Gu

机构信息

Department of Neurosurgery, Brain Tumor Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

出版信息

Brain Tumor Res Treat. 2018 Oct;6(2):101-104. doi: 10.14791/btrt.2018.6.e18.

DOI:10.14791/btrt.2018.6.e18

PMID:30381926

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6212688/

Abstract

Pheochromocytoma (PCC) is a neuroendocrine tumor that mainly arises from the medulla of the adrenal gland. Some PCCs become malignant and metastasize to other organs. For example, it typically involves skeletal system, liver, lung, and regional lymph nodes. However, only a few cases of PCC with brain metastasis have been reported worldwide. We report a case of metastatic brain tumor from PCC in South Korea in 2016. A 52-year-old man presented with headache, dizziness and motor aphasia. He had a medical history of PCC with multi-organ metastasis, previously underwent several operations, and was treated with chemotherapy and radiotherapy. Brain MRIs showed a brain tumor on the left parietal lobe. Postoperative pathology confirmed that the metastatic brain tumor derived from malignant PCC. This is the first report PCC with brain metastasis in South Korea.

摘要

嗜铬细胞瘤（PCC）是一种主要起源于肾上腺髓质的神经内分泌肿瘤。一些嗜铬细胞瘤会恶变并转移至其他器官。例如，它通常累及骨骼系统、肝脏、肺和区域淋巴结。然而，全球仅报道了少数几例发生脑转移的嗜铬细胞瘤。我们报告了2016年韩国一例嗜铬细胞瘤脑转移瘤病例。一名52岁男性出现头痛、头晕和运动性失语。他有嗜铬细胞瘤伴多器官转移的病史，此前接受过多次手术，并接受了化疗和放疗。脑部磁共振成像显示左顶叶有一个脑肿瘤。术后病理证实该脑转移瘤源自恶性嗜铬细胞瘤。这是韩国首例关于嗜铬细胞瘤脑转移的报告。