从 Pleione bulbocodioides 的假鳞茎中提取的葡萄糖氧基苯甲基琥珀酸酯衍生物的保肝活性。
Hepatoprotective activity of glucosyloxybenzyl succinate derivatives from the pseudobulbs of Pleione bulbocodioides.
机构信息
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.
Beijing Key Laboratory of Drug Target Research and Drug Screening, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.
出版信息
Phytochemistry. 2019 Jan;157:71-81. doi: 10.1016/j.phytochem.2018.10.003. Epub 2018 Oct 30.
Ten previously undescribed glucosyloxybenzyl succinate derivatives, pleionosides A-J, and fifteen known compounds were isolated from the pseudobulbs of Pleione bulbocodioides (Franch.) Rolfe. Their structures were elucidated by a combination of MS and NMR data, physical and chemical methods and a comparison with known compounds. Furthermore, three compounds exhibited potent hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced HepG2 cell damage in in vitro assays, with cell survival rates of 31.89%, 31.52% and 31.97% at 10 μM. Four compounds exhibited moderate antioxidant activity with increasing viability at 10 μM of 36.1%, 45.0%, 25.5% and 20.7%.
从 Pleione bulbocodioides（Franch.） Rolfe 的假鳞茎中分离得到了 10 种以前未描述的葡萄糖氧基苄基琥珀酸酯衍生物，即 pleionosides A-J，以及 15 种已知化合物。通过 MS 和 NMR 数据、物理化学方法以及与已知化合物的比较，确定了它们的结构。此外，三种化合物在体外试验中对 N-乙酰对氨基苯酚（APAP）诱导的 HepG2 细胞损伤表现出很强的保肝活性，在 10μM 时细胞存活率分别为 31.89%、31.52%和 31.97%。四种化合物表现出中等的抗氧化活性，在 10μM 时细胞活力分别增加了 36.1%、45.0%、25.5%和 20.7%。
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