Department of Obstetrics and Gynecology, Erasmus MC, University Medical Centre Rotterdam, PO Box 2040, 3000 CA Rotterdam, the Netherlands.
Division of Human Nutrition, Wageningen University, PO Box 17, 6700 AA Wageningen, the Netherlands.
Clin Nutr. 2019 Oct;38(5):2333-2341. doi: 10.1016/j.clnu.2018.10.011. Epub 2018 Oct 24.
BACKGROUND & AIM: Several studies show the importance of periconceptional maternal dietary patterns on human embryonic growth. Healthy paternal nutrition has been associated with better semen quality and fecundability, however, evidence on the impact on pregnancy outcome is limited. Therefore, the aim of this study was to investigate the association between preconception paternal dietary patterns and first trimester embryonic growth using the parameters longitudinal crown-rump length (CRL) and embryonic volume (EV).
A total of 638 couples were enrolled in the Rotterdam Periconceptional Cohort and received longitudinal three dimensional transvaginal ultrasound scans from 7 up to 12 weeks of gestation. Virtual reality software was used to perform offline measurements of the embryonic CRL and EV. Food frequency questionnaires (FFQ) were used to estimate habitual food intake in couples. Principal component analysis (PCA) was performed to identify paternal and maternal dietary patterns. Linear mixed models adjusted for potential confounders were applied to analyze associations between paternal and maternal dietary patterns and embryonic growth parameters.
The paternal dietary patterns retrieved were identified as "Whole wheat grains and Vegetables", "Sauces and Snacks Refined Grains", "Fish and Legumes" and explained 27.5% of the total variance of the dietary intake. No significant additional effects, independent of maternal dietary patters and other maternal and paternal potential confounders, were shown of these paternal dietary patterns on embryonic growth in spontaneous or IVF/ICSI pregnancies.
No significant effects of paternal dietary patterns independent of maternal dietary patters and other parental potential confounders on embryonic growth parameters could be established in spontaneous or IVF/ICSI pregnancies. The biological importance of paternal nutrition on semen quality, however, supports the need of periconceptional tailored nutritional counselling of couples trying to conceive.
多项研究表明，围孕期母体的饮食模式对胚胎生长具有重要影响。健康的父体营养与更好的精液质量和生育能力有关，但关于其对妊娠结局影响的证据有限。因此，本研究旨在探讨父体的围孕期饮食模式与妊娠早期胚胎生长之间的关系，使用参数纵向头臀长（CRL）和胚胎体积（EV）来评估。
共有 638 对夫妇参加了鹿特丹围孕期队列，并在妊娠 7 至 12 周时接受了三次经阴道超声扫描。使用虚拟现实软件对胚胎的 CRL 和 EV 进行离线测量。使用食物频率问卷（FFQ）来估计夫妇的习惯性食物摄入。采用主成分分析（PCA）来识别父体和母体的饮食模式。应用线性混合模型调整潜在混杂因素，分析父体和母体饮食模式与胚胎生长参数之间的关系。
确定了父体饮食模式为“全麦谷物和蔬菜”、“酱汁和零食精制谷物”、“鱼类和豆类”，解释了总饮食摄入的 27.5%。在自然妊娠或 IVF/ICSI 妊娠中，这些父体饮食模式与胚胎生长之间没有显示出显著的额外影响，独立于母体饮食模式和其他母体和父体潜在混杂因素。
在自然妊娠或 IVF/ICSI 妊娠中，父体饮食模式独立于母体饮食模式和其他父母潜在混杂因素对胚胎生长参数没有显著影响。然而，父体营养对精液质量的生物学重要性支持了对尝试受孕的夫妇进行围孕期个体化营养咨询的必要性。
