Bhanvadia Sumeet K
USC/Norris Comprehensive Cancer Center, Keck School of Medicine, USC Institute of Urology, 1441 Eastlake Ave, Suite 7416, Los Angeles, CA, 90094, USA.
Curr Urol Rep. 2018 Nov 9;19(12):111. doi: 10.1007/s11934-018-0860-6.
Bladder cancer (BC) is the second most common genitourinary malignancy, with a growing population of survivors globally. Over the past two decades, there has been a growing awareness of not only the oncologic, but also the quality of life ramifications of a BC diagnosis, treatment, and surveillance. In the current review, the literature surrounding the many domains that encompass bladder cancer survivorship is summarized and analyzed.
There have been ongoing efforts to decrease perioperative morbidity, particularly in patients undergoing radical cystectomy, with mixed results. There is a growing emphasis on the short and long-term health-related quality of life (HR-QoL) impacts of bladder cancer spanning the domains of physical and mental QoL related to urinary function, sexual function, and financial and psychological burden, with validated measures specific to BC patients. There continue to be disparities in oncologic outcomes by race and gender. The impact of BC is prolonged and there is an unmet need for long term support and survivorship resources to address this. There is a growing global population of bladder cancer patients, and their needs are complex and vary by stage, treatment, and certain demographic features. Outcome-centered perioperative strategies show potential to diminish treatment morbidity, and validated BC specific HR-QoL tools have helped to define the impact and burden of BC, but there continue to be large areas of unmet need that warrant greater study and intervention.
膀胱癌(BC)是第二常见的泌尿生殖系统恶性肿瘤,全球幸存者人数不断增加。在过去二十年中,人们不仅越来越意识到BC诊断、治疗和监测对肿瘤学的影响,也越来越关注其对生活质量的影响。在本综述中,总结并分析了围绕膀胱癌幸存者诸多领域的文献。
一直在努力降低围手术期发病率,尤其是在接受根治性膀胱切除术的患者中,但结果不一。越来越强调膀胱癌对短期和长期健康相关生活质量(HR-QoL)的影响,涵盖与泌尿功能、性功能以及经济和心理负担相关的身体和心理生活质量领域,并有针对BC患者的有效测量方法。在肿瘤学结局方面,种族和性别差异仍然存在。BC的影响持续时间较长,长期支持和幸存者资源方面的需求尚未得到满足。全球膀胱癌患者人数不断增加,他们的需求复杂,因阶段、治疗和某些人口统计学特征而异。以结局为中心的围手术期策略显示出降低治疗发病率的潜力,经过验证的特定于BC的HR-QoL工具有助于确定BC的影响和负担,但仍有很大的未满足需求领域,需要更多的研究和干预。