OM - 8980与金诺芬治疗类风湿关节炎的双盲多中心研究。
A double blind multicentre study of OM-8980 and auranofin in rheumatoid arthritis.
作者信息
Vischer T L
机构信息
Hôpital Cantonal Universitaire, Geneva, Switzerland.
出版信息
Ann Rheum Dis. 1988 Jul;47(7):582-7. doi: 10.1136/ard.47.7.582.
Abstract
The therapeutic efficacy of the immunomodulator OM-8980 in rheumatoid arthritis was compared with that of auranofin, an oral gold salt, in a double blind, randomised multicentre study lasting six months. Seventy patients were treated with auranofin and 75 with OM-8980. The patients of both groups improved significantly at three and six months for all the clinical parameters observed: Ritchie index, number of swollen joints, morning stiffness, pain, grip strength, intake of non-steroidal anti-inflammatory drugs, and erythrocyte sedimentation rate. No serious side effects were observed in either group. The patients receiving auranofin had more adverse reactions, mainly affecting the gastrointestinal system.
摘要
在一项为期六个月的双盲、随机多中心研究中，将免疫调节剂OM - 8980与口服金盐制剂金诺芬在类风湿性关节炎中的治疗效果进行了比较。70例患者接受金诺芬治疗，75例患者接受OM - 8980治疗。两组患者在观察的所有临床参数方面，即里奇指数、关节肿胀数、晨僵、疼痛、握力、非甾体抗炎药摄入量和红细胞沉降率，在三个月和六个月时均有显著改善。两组均未观察到严重副作用。接受金诺芬治疗的患者不良反应更多，主要影响胃肠道系统。
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