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1
Piezo1 mediates angiogenesis through activation of MT1-MMP signaling.Piezo1 通过激活 MT1-MMP 信号来介导血管生成。
Am J Physiol Cell Physiol. 2019 Jan 1;316(1):C92-C103. doi: 10.1152/ajpcell.00346.2018. Epub 2018 Nov 14.
2
Fluid shear stress and sphingosine 1-phosphate activate calpain to promote membrane type 1 matrix metalloproteinase (MT1-MMP) membrane translocation and endothelial invasion into three-dimensional collagen matrices.流体切应力和鞘氨醇 1-磷酸激活钙蛋白酶以促进膜型 1 基质金属蛋白酶 (MT1-MMP) 膜易位和内皮细胞侵入三维胶原基质。
J Biol Chem. 2011 Dec 9;286(49):42017-42026. doi: 10.1074/jbc.M111.290841. Epub 2011 Oct 14.
3
Hic-5 mediates the initiation of endothelial sprouting by regulating a key surface metalloproteinase.Hic-5通过调节一种关键的表面金属蛋白酶来介导内皮细胞芽生的起始。
J Cell Sci. 2016 Feb 15;129(4):743-56. doi: 10.1242/jcs.170571. Epub 2016 Jan 14.
4
Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release.内皮阳离子通道PIEZO1通过介导血流诱导的ATP释放来控制血压。
J Clin Invest. 2016 Dec 1;126(12):4527-4536. doi: 10.1172/JCI87343. Epub 2016 Oct 31.
5
Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells.新生血管与壁细胞之间的串扰将MT1-MMP的位点特异性表达导向内皮尖端细胞。
J Cell Sci. 2007 May 1;120(Pt 9):1607-14. doi: 10.1242/jcs.000679. Epub 2007 Apr 3.
6
Fluid shear stress promotes proprotein convertase-dependent activation of MT1-MMP.流体剪切应力促进MT1-MMP的前蛋白转化酶依赖性激活。
Biochem Biophys Res Commun. 2015 May 8;460(3):596-602. doi: 10.1016/j.bbrc.2015.03.075. Epub 2015 Mar 20.
7
Establishment of a three-dimensional model to study human uterine angiogenesis.建立研究人子宫血管生成的三维模型。
Mol Hum Reprod. 2018 Feb 1;24(2):74-93. doi: 10.1093/molehr/gax064.
8
Piezo1 channel activation stimulates ATP production through enhancing mitochondrial respiration and glycolysis in vascular endothelial cells.机械敏感离子通道 1(Piezo1)的激活可通过增强血管内皮细胞中线粒体呼吸和糖酵解来刺激 ATP 的产生。
Br J Pharmacol. 2023 Jul;180(14):1862-1877. doi: 10.1111/bph.16050. Epub 2023 Feb 27.
9
Piezo1 mediates endothelial atherogenic inflammatory responses via regulation of YAP/TAZ activation.Piezo1 通过调节 YAP/TAZ 的激活来介导内皮细胞致动脉粥样硬化炎症反应。
Hum Cell. 2022 Jan;35(1):51-62. doi: 10.1007/s13577-021-00600-5. Epub 2021 Oct 4.
10
Endothelial cell Piezo1 mediates pressure-induced lung vascular hyperpermeability via disruption of adherens junctions.内皮细胞 Piezo1 通过破坏黏附连接介导压力诱导的肺血管通透性增加。
Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12980-12985. doi: 10.1073/pnas.1902165116. Epub 2019 Jun 11.

引用本文的文献

1
Piezo1 in heart failure: A new perspective from cytomechanical sensing to diverse cellular pathways.Piezo1在心力衰竭中的作用:从细胞力学感知到多种细胞途径的新视角。
Mol Biol Rep. 2025 Sep 3;52(1):862. doi: 10.1007/s11033-025-10969-3.
2
The dual role of Piezo1 in tumor cells and immune cells: a new target for cancer therapy.Piezo1在肿瘤细胞和免疫细胞中的双重作用:癌症治疗的新靶点。
Front Immunol. 2025 Jul 31;16:1635388. doi: 10.3389/fimmu.2025.1635388. eCollection 2025.
3
SETD2 drives METTL14-mediated mA to suppress Piezo1 Attenuation and activate TGM2 to promote pulmonary hypertension.SET结构域蛋白2驱动METTL14介导的N6-甲基腺苷修饰以抑制Piezo1衰减并激活转谷氨酰胺酶2以促进肺动脉高压。
Cell Mol Life Sci. 2025 Aug 8;82(1):302. doi: 10.1007/s00018-025-05809-3.
4
Roles of Piezo1 in chronic inflammatory diseases and prospects for drug treatment (Review).Piezo1在慢性炎症性疾病中的作用及药物治疗前景(综述)
Mol Med Rep. 2025 Jul;32(1). doi: 10.3892/mmr.2025.13565. Epub 2025 May 16.
5
Mechanotransduction in Development: A Focus on Angiogenesis.发育过程中的机械转导:聚焦于血管生成
Biology (Basel). 2025 Mar 27;14(4):346. doi: 10.3390/biology14040346.
6
Endothelial Piezo1 stimulates angiogenesis to offer protection against intestinal ischemia-reperfusion injury in mice.内皮细胞Piezo1刺激血管生成,为小鼠肠道缺血再灌注损伤提供保护。
Mol Med. 2025 Apr 22;31(1):147. doi: 10.1186/s10020-025-01197-3.
7
Deciphering mechanical cues in the microenvironment: from non-malignant settings to tumor progression.解读微环境中的机械信号:从非恶性环境到肿瘤进展
Biomark Res. 2025 Jan 23;13(1):11. doi: 10.1186/s40364-025-00727-9.
8
Advances in mechanotransduction and sonobiology: effects of audible acoustic waves and low-vibration stimulations on mammalian cells.机械转导与声生物学进展:可听声波和低振动刺激对哺乳动物细胞的影响
Biophys Rev. 2024 Oct 7;16(6):783-812. doi: 10.1007/s12551-024-01242-1. eCollection 2024 Dec.
9
Tension at the gate: sensing mechanical forces at the blood-brain barrier in health and disease.血脑屏障处的张力:健康与疾病状态下血脑屏障对机械力的感知
J Neuroinflammation. 2024 Dec 18;21(1):325. doi: 10.1186/s12974-024-03321-2.
10
The Role of Mechanosensitive Piezo Channels in Chronic Pain.机械敏感Piezo通道在慢性疼痛中的作用
J Pain Res. 2024 Dec 11;17:4199-4212. doi: 10.2147/JPR.S490459. eCollection 2024.

本文引用的文献

1
Src-dependent phosphorylation of caveolin-1 Tyr-14 promotes swelling and release of caveolae.小窝蛋白-1酪氨酸14位点的Src依赖性磷酸化促进小窝的肿胀和释放。
Mol Biol Cell. 2016 Jul 1;27(13):2090-106. doi: 10.1091/mbc.E15-11-0756. Epub 2016 May 11.
2
Quantitative phospho-proteomics reveals the Plasmodium merozoite triggers pre-invasion host kinase modification of the red cell cytoskeleton.定量磷酸化蛋白质组学揭示疟原虫裂殖子触发红细胞细胞骨架的入侵前宿主激酶修饰。
Sci Rep. 2016 Feb 2;6:19766. doi: 10.1038/srep19766.
3
Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension.去除细胞骨架的机械保护作用后发现,PIEZO1由双层张力控制。
Nat Commun. 2016 Jan 20;7:10366. doi: 10.1038/ncomms10366.
4
Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension.Piezo1离子通道的机械敏感性可通过细胞膜张力进行调节。
Elife. 2015 Dec 8;4:e12088. doi: 10.7554/eLife.12088.
5
Architecture of the mammalian mechanosensitive Piezo1 channel.哺乳动物机械敏感 Piezo1 通道的结构。
Nature. 2015 Nov 5;527(7576):64-9. doi: 10.1038/nature15247. Epub 2015 Sep 21.
6
Piezo1 regulates mechanotransductive release of ATP from human RBCs.Piezo1调节人红细胞中ATP的机械转导释放。
Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11783-8. doi: 10.1073/pnas.1507309112. Epub 2015 Sep 8.
7
Piezo1 ion channel pore properties are dictated by C-terminal region.Piezo1离子通道的孔道特性由C端区域决定。
Nat Commun. 2015 May 26;6:7223. doi: 10.1038/ncomms8223.
8
Chemical activation of the mechanotransduction channel Piezo1.机械转导通道Piezo1的化学激活
Elife. 2015 May 22;4:e07369. doi: 10.7554/eLife.07369.
9
Piezo1 links mechanical forces to red blood cell volume.Piezo1将机械力与红细胞体积联系起来。
Elife. 2015 May 22;4:e07370. doi: 10.7554/eLife.07370.
10
Fluid shear stress promotes proprotein convertase-dependent activation of MT1-MMP.流体剪切应力促进MT1-MMP的前蛋白转化酶依赖性激活。
Biochem Biophys Res Commun. 2015 May 8;460(3):596-602. doi: 10.1016/j.bbrc.2015.03.075. Epub 2015 Mar 20.