O'Byrne Michael L, Levi Daniel S
Division of Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Center for Pediatric Clinical Effectiveness, Leonard Davis Institute, University of Pennsylvania, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA.
Division of Cardiology, UCLA Mattel Children's Hospital, University of California Los Angeles Medical School, 200 UCLA Medical Plaza #330, Los Angeles, CA 90095, USA.
Interv Cardiol Clin. 2019 Jan;8(1):11-21. doi: 10.1016/j.iccl.2018.08.008.
This article describes current devices and indications for transcatheter device closure of atrial septal defect (TC-ASD) and patent foramen ovale in children and young adults. TC-ASD has a proven record of efficacy and safety, but device erosion raises questions about the relative safety of TC-ASD versus operative open heart surgical ASD closure. New devices for ASD closure with properties to reduce risk of erosion are being developed. Recent studies demonstrating superiority of patent foramen ovale device closure over medical therapy for cryptogenic stroke may lead to changes in practice for structural/interventional cardiologists. Care should be taken in extrapolating data to children and younger adults.
本文描述了用于儿童和年轻成人经导管装置闭合房间隔缺损(TC-ASD)及卵圆孔未闭的现有装置和适应证。TC-ASD已有经证实的疗效和安全性记录,但装置侵蚀引发了关于TC-ASD与外科直视心脏手术闭合ASD相比相对安全性的问题。正在研发具有降低侵蚀风险特性的新型ASD闭合装置。近期研究表明,卵圆孔未闭装置闭合优于隐源性卒中的药物治疗,这可能会改变结构/介入心脏病学家的临床实践。在将数据外推至儿童和更年轻成人时应谨慎。