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利用虚拟现实进行药物发现:新型先导化合物的有前途的新途径。

Using virtual reality for drug discovery: a promising new outlet for novel leads.

机构信息

a School of Biological Science , Jining Medical University , Jining , China.

b Key Laboratory of Biomass Chemical Engineering of Ministry of Education , College of Chemical and Biological Engineering, Zhejiang University , Hangzhou , China.

出版信息

Expert Opin Drug Discov. 2018 Dec;13(12):1103-1114. doi: 10.1080/17460441.2018.1546286. Epub 2018 Nov 20.

Abstract

: Virtual reality (VR) environments are increasingly being used by researchers in various fields in addition to being increasingly integrated into various areas of human life, ranging from videogames to different industrial uses. VR can be used to create interactive and multimodal sensory stimuli and thus offers unique advantages over other computer-based approaches for scientific research and molecular-level applications. Consequently, VR is starting to be used in novel drug development, such as in drug discovery, and rational drug design. : In this review, the authors discuss the basic development of VR technology, including the available hardware and software. The latest advances of VR technology in novel drug development are then detailed, and the VR programs that can be applied in relevant studies are highlighted. : VR will lead to a revolution in pharmaceutical development. However, there are still obstacles to the successful and extensive application of VR to drug development, including the demand for further improvements to the available hardware and software and the various limitations described with regard to accuracy and precision. As technology continues to improve, the barriers to the widespread adoption of VR will diminish and VR technologies will play an increasingly important role in novel drug development.

摘要

虚拟现实(VR)环境除了越来越多地融入人类生活的各个领域(从视频游戏到各种工业用途)之外,也越来越多地被各个领域的研究人员所使用。VR 可用于创建交互式和多模式感官刺激,因此与其他基于计算机的科学研究和分子水平应用方法相比具有独特的优势。因此,VR 开始用于新型药物开发,例如药物发现和合理药物设计。

在这篇综述中,作者讨论了 VR 技术的基本发展情况,包括现有的硬件和软件。然后详细介绍了 VR 技术在新型药物开发中的最新进展,并突出了可应用于相关研究的 VR 程序。

VR 将引发药物开发的革命。但是,要成功和广泛地将 VR 应用于药物开发仍然存在障碍,包括对现有硬件和软件的进一步改进的需求,以及关于准确性和精度的各种限制。随着技术的不断进步,广泛采用 VR 的障碍将减少,VR 技术将在新型药物开发中发挥越来越重要的作用。

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