仿生支架在骨组织工程中的应用
Biomimetic Scaffolds for Bone Tissue Engineering.
机构信息
Department of Molecular Science and Technology, Ajou University, Suwon, South Korea.
Department of Biomedical Engineering, Pukyong National University, Busan, South Korea.
出版信息
Adv Exp Med Biol. 2018;1064:109-121. doi: 10.1007/978-981-13-0445-3_7.
The use of biomimetic scaffolds for bone tissue engineering has been studied for a long time. Biomimetic scaffolds can assist and accelerate bone regeneration that is similar to that of authentic tissue, which represents the environment of cells in a living organism. Currently, numerous biomaterials have been reported for use as a biomimetic scaffold. This review focuses on the design of biomimetic scaffolds, kinds of biomaterials and methods used to fabricate biomimetic scaffolds, growth factors used with biomimetic scaffold for bone regeneration, mobilization of biological agents into biomimetic scaffolds, and studies on (pre)clinical bone regeneration from biomimetic scaffolds. Then, future prospects for biomimetic scaffolds are discussed.
仿生支架在骨组织工程中的应用已经研究了很长时间。仿生支架可以辅助和加速类似于真实组织的骨再生，代表了生物体中细胞的环境。目前，已经有许多生物材料被报道用于作为仿生支架。本文主要介绍了仿生支架的设计、仿生支架所使用的生物材料的种类和制备方法、用于骨再生的仿生支架中的生长因子、生物制剂向仿生支架中的迁移以及仿生支架的（前）临床骨再生研究，最后对仿生支架的未来前景进行了讨论。
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