波瓦罗夫反应在药物化学中的最新进展。
Recent advances of the Povarov reaction in medicinal chemistry.
作者信息
Ghashghaei Ouldouz, Masdeu Carme, Alonso Concepción, Palacios Francisco, Lavilla Rodolfo
机构信息
Laboratory of Medicinal Chemistry, Faculty of Pharmacy and Food Sciences and Institute of Biomedicine (IBUB), University of Barcelona, Av. de Joan XXIII, 27-31, 08028 Barcelona, Spain.
Departamento de Química Orgánica I, Facultad de Farmacia, University of the Basque Country, UPV/EHU Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain.
出版信息
Drug Discov Today Technol. 2018 Nov;29:71-79. doi: 10.1016/j.ddtec.2018.08.004. Epub 2018 Aug 28.
The Povarov multicomponent reaction consists on the condensation of an aniline, an aldehyde, and an activated olefin to generate a tetrahydroquinoline adduct with 3 diversity points. Hereby, we report the main features of this transformation and its uses in medicinal chemistry. Relevant examples of the impact of Povarov adducts in different therapeutic areas are provided.
波瓦罗夫多组分反应包括苯胺、醛和活化烯烃的缩合反应，生成具有3个多样性位点的四氢喹啉加合物。在此，我们报道了这种转化反应的主要特点及其在药物化学中的应用。文中还提供了波瓦罗夫加合物在不同治疗领域所产生影响的相关实例。
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