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儿童哮喘患病率:伊朗首次基于全国人口的调查。

Paediatric asthma prevalence: The first national population-based survey in Iran.

作者信息

Fazlollahi Mohammad Reza, Najmi Mehdi, Fallahnezhad Mojtaba, Sabetkish Nastaran, Kazemnejad Anoshirvan, Bidad Katayoon, Shokouhi Shoormasti Raheleh, Mahloujirad Maryam, Pourpak Zahra, Moin Mostafa

机构信息

Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Center of Non-communicable Diseases Management, Deputy for health, Ministry of Health and Medical Education, Tehran, Iran.

出版信息

Clin Respir J. 2019 Jan;13(1):14-22. doi: 10.1111/crj.12975. Epub 2019 Jan 11.

Abstract

BACKGROUND

The actual prevalence of paediatric asthma as a worldwide chronic disease has been surveyed in developed countries. However, no sufficient survey has been conducted in most of the eastern developing countries. Herein, we took measures to evaluate the prevalence of paediatric asthma in Iran.

METHODS

In this national cross-sectional study, the prevalence of asthma symptoms was estimated throughout the country using a randomized multistage stratified cluster sampling method in 16 410 and 16 850 individuals aged 6-7 and 13-14 years, respectively. A validated questionnaire including core questions of the International Study of Asthma and Allergies in Childhood (ISAAC) was applied between November 2015 and February 2016.

RESULTS

The total prevalence of asthma was 10.9% (n = 3624) (95% confidence interval [CI]: 10.6%-11.2%) which was significantly higher among 13- to 14-year olds compared to a younger age group (12.4% vs. 9.4%, P < 0.001), males versus females (12.1% vs. 9.8%, P < 0.001) and residents of urban compared to rural areas (P = 0.003). The prevalence of severe asthma was 3.9%, being significantly more prevalent in higher age groups and male individuals (P < 0.001). A significant relationship was found between asthma and passive smoking in both 6- to 7- and 13- to 14-year olds (P < 0.001).

CONCLUSIONS

The prevalence of asthma and severe asthma in the paediatric population of Iran was similar to other developing countries. It is recommended to pay special attention to urban regions, male individuals and higher age groups for better controlling of asthma. Nevertheless, further national surveys are necessary to determine the trend of paediatric asthma in Iran.

摘要

背景

发达国家已对作为一种全球慢性疾病的儿童哮喘实际患病率进行了调查。然而,大多数东部发展中国家尚未进行充分的调查。在此,我们采取措施评估伊朗儿童哮喘的患病率。

方法

在这项全国性横断面研究中,分别采用随机多阶段分层整群抽样方法,对全国16410名6至7岁和16850名13至14岁个体的哮喘症状患病率进行了估计。在2015年11月至2016年2月期间应用了一份经过验证的问卷,其中包括儿童哮喘和过敏国际研究(ISAAC)的核心问题。

结果

哮喘的总患病率为10.9%(n = 3624)(95%置信区间[CI]:10.6% - 11.2%),13至14岁年龄组的患病率显著高于较年轻年龄组(12.4%对9.4%,P < 0.001),男性高于女性(12.1%对9.8%,P < 0.001),城市居民高于农村居民(P = 0.003)。重度哮喘的患病率为3.9%,在较高年龄组和男性个体中更为普遍(P < 0.001)。在6至7岁和13至14岁儿童中,均发现哮喘与被动吸烟之间存在显著关联(P < 0.001)。

结论

伊朗儿童人群中哮喘和重度哮喘的患病率与其他发展中国家相似。建议特别关注城市地区、男性个体和较高年龄组,以更好地控制哮喘。然而,有必要进一步开展全国性调查以确定伊朗儿童哮喘的趋势。

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