Department of Public Health and Clinical Medicine, Epidemiology and Global Health, Umeå University, Umeå, Sweden.
Department of Public Health and Clinical Medicine, Family Medicine, Umeå University, Umeå, Sweden.
Acta Paediatr. 2019 Jun;108(6):1140-1143. doi: 10.1111/apa.14669. Epub 2018 Dec 14.
In 2012, revised criteria for diagnosing childhood coeliac disease were published by the European Society for Paediatric Gastroenterology, Hepatology and Nutrition and incorporated into the revised Swedish guidelines the same year. These made it possible, in certain cases, to diagnose coeliac disease without taking small bowel biopsies. This survey assessed the extent to which the new guidelines were implemented by Swedish paediatric clinics two years after their introduction.
In October 2014, we distributed a paper questionnaire including five questions on diagnostic routines to the 40 paediatric clinics in university or regional hospitals in Sweden that perform small bowel biopsies.
All 36 (90%) clinics that responded used anti-tissue transglutaminase antibodies as the initial diagnostic test and some also used serological markers. Most clinics (81%) used endoscopy and took multiple duodenal biopsies, whereas only a few (19%) occasionally employed a suction capsule. Almost all clinics (86%) omitted taking small bowel biopsies in symptomatic children with repeatedly high coeliac serology and positive genotyping, thereby avoiding the need for invasive endoscopy under anaesthesia.
The 2012 Swedish Paediatric Coeliac Disease Diagnostic Guidelines had been widely accepted and implemented in routine health care two years after their introduction.
2012 年,欧洲儿科胃肠病学、肝病学和营养学学会发布了修订后的儿童乳糜泻诊断标准,并于同年纳入修订后的瑞典指南。这些标准使得在某些情况下可以在不进行小肠活检的情况下诊断乳糜泻。本调查评估了新指南在引入两年后瑞典儿科诊所实施的程度。
2014 年 10 月,我们向瑞典大学或地区医院的 40 家进行小肠活检的儿科诊所发放了一份纸质问卷,其中包括五个关于诊断程序的问题。
所有 36 家(90%)做出回应的诊所均将抗组织转谷氨酰胺酶抗体作为初始诊断试验,一些诊所还使用了血清标志物。大多数诊所(81%)使用内窥镜并进行多次十二指肠活检,而只有少数诊所(19%)偶尔使用抽吸胶囊。几乎所有诊所(86%)在症状性儿童出现反复高乳糜泻血清学和阳性基因分型时避免进行小肠活检,从而避免了在麻醉下进行有创内窥镜检查的需要。
2012 年瑞典儿科乳糜泻诊断指南在引入两年后已被广泛接受并在常规医疗保健中实施。