血清维生素 D 水平与麻疹抗体滴度呈负相关：NHANES，2001-2004 的横断面分析。
Inverse relationship between serum vitamin D level and measles antibody titer: A cross-sectional analysis of NHANES, 2001-2004.
机构信息
Department of Dermatology, Tri-Service General Hospital; and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital; and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.
出版信息
PLoS One. 2018 Nov 30;13(11):e0207798. doi: 10.1371/journal.pone.0207798. eCollection 2018.
BACKGROUND
In recent years, researchers have illuminated many non-skeletal actions of vitamin D including host defense against various pathogens and vaccine immunology. The purpose of our study was to explore the potential association between serum vitamin D levels and measles antibody titers.
METHODS
The biochemical profiles and de-identified information were accessed from the 2001 to 2004 National Health and Nutrition Examination Survey (NHANES). Participants were divided into quartiles according to their measles antibody titers.
RESULTS
A total of 5,681 participants were analyzed in our study. Participants in the highest quartile of measles antibody titer had significantly lower serological levels of 25-hydroxyvitamin D [25(OH)D] than those in the lower quartiles (53.90 vs. 58.70 nmol/L, a decrease of 8.18%) (p < 0.001). After full adjustment of confounders, the adjusted ß coefficient of 25(OH)D was -0.006 (p<0.001). A decreasing tendency of 25(OH)D among quartiles of measles antibody titers was obvious (p for trend <0.001). The negative association in seropositive subjects remained statistically significant only in non-Hispanic black population before adjustment for age, gender, and other covariates (p<0.05).
CONCLUSION
Our study highlights the negative association between serum 25(OH)D levels and measles antibody titers.
背景
近年来，研究人员揭示了维生素 D 的许多非骨骼作用，包括宿主对各种病原体的防御和疫苗免疫学。我们研究的目的是探讨血清维生素 D 水平与麻疹抗体滴度之间的潜在关联。
方法
从 2001 年至 2004 年国家健康和营养调查（NHANES）中获取生化特征和去识别信息。根据麻疹抗体滴度将参与者分为 quartiles。
结果
本研究共分析了 5681 名参与者。麻疹抗体滴度最高 quartile 的参与者血清 25-羟维生素 D [25(OH)D] 水平明显低于低 quartile 参与者（53.90 与 58.70 nmol/L，降低了 8.18%）（p < 0.001）。在充分调整混杂因素后，25(OH)D 的调整β系数为-0.006（p<0.001）。麻疹抗体滴度 quartiles 中 25(OH)D 的下降趋势明显（p<0.001）。在调整年龄、性别和其他协变量之前，非西班牙裔黑人群体中血清阳性者的负相关仍然具有统计学意义（p<0.05）。
结论
我们的研究强调了血清 25(OH)D 水平与麻疹抗体滴度之间的负相关。
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