人类内源性逆转录病毒对母体吸烟的产前暴露的转录活性。
Transcriptional Activity of Human Endogenous Retroviruses in Response to Prenatal Exposure of Maternal Cigarette Smoking.
机构信息
Department of Public Health and Pediatric Sciences, Citoimmunodiagnostics Laboratory, University of Turin, Medical School, Turin, Italy.
Infectious Diseases Unit, Department of Pediatrics, Regina Margherita Children's Hospital, University of Turin, Turin, Italy.
出版信息
Am J Perinatol. 2019 Aug;36(10):1060-1065. doi: 10.1055/s-0038-1675768. Epub 2018 Nov 30.
OBJECTIVE
Transcription of human endogenous retrovirus (HERV) elements is usually suppressed by epigenetic factors such as DNA methylation and heterochromatin silencing by histone modifications. There is an association between maternal smoking during pregnancy and DNA methylation levels in placental tissue and in DNA from cord blood.
STUDY DESIGN
We assessed the transcriptional activity of HERV-H, HERV-K, and HERV-W in umbilical cord blood from 47 term babies unexposed to tobacco smoke in utero and 23 term babies exposed to tobacco smoke in utero.
RESULTS
In our population, the HERV-H, HERV-K, and HERV-W families were always transcriptionally active, and the levels of all HERVs (H, K, W) were significantly higher in unexposed than smoke-exposed babies.
CONCLUSION
This study provides preliminary information about the transcriptional activity of HERV-H, HERV-K, and HERV-W families in human umbilical cord blood.
目的
人类内源性逆转录病毒（HERV）元件的转录通常受到表观遗传因素的抑制，如 DNA 甲基化和组蛋白修饰的异染色质沉默。母亲在怀孕期间吸烟与胎盘组织和脐带血中 DNA 的 DNA 甲基化水平之间存在关联。
研究设计
我们评估了 47 名未接触宫内烟草烟雾的足月婴儿和 23 名接触宫内烟草烟雾的足月婴儿脐带血中 HERV-H、HERV-K 和 HERV-W 的转录活性。
结果
在我们的人群中，HERV-H、HERV-K 和 HERV-W 家族始终具有转录活性，未暴露于烟雾的婴儿中所有 HERV（H、K、W）的水平均明显高于暴露于烟雾的婴儿。
结论
本研究提供了关于人类脐带血中 HERV-H、HERV-K 和 HERV-W 家族转录活性的初步信息。
Zotero 插件