一例伴有严重难治性血小板减少症但无皮肤表现的输血后紫癜病例。

A Case of Posttransfusion Purpura with Severe Refractory Thrombocytopenia but No Cutaneous Manifestations.

作者信息

Bhamra Jagjit Singh, Iversen Per Ole, Titze Thomas Kjenner, Tjønnfjord Geir Erland, Akkök Çiğdem Akalın

机构信息

Department of Immunology and Transfusion Medicine, Oslo University Hospital, Oslo, Norway.

Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

出版信息

Case Rep Hematol. 2018 Oct 29;2018:8187659. doi: 10.1155/2018/8187659. eCollection 2018.

DOI:10.1155/2018/8187659

PMID:30510818

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6231382/

Abstract

Posttransfusion purpura is a serious adverse effect of transfusion due to HPA-antibodies. A young female was diagnosed with acute leukaemia, and treatment commenced. Severe thrombocytopenia ensued. No platelet increment was achieved despite transfusions with buffy coat, HLA-compatible, and HPA-1a negative platelets. The workup indicated the presence of anti-HPA-1a. When the diagnosis of posttransfusion purpura was sufficiently substantiated, she had experienced a fatal intracerebral haemorrhage.

摘要

输血后紫癜是由人类血小板抗原（HPA）抗体引起的一种严重的输血不良反应。一名年轻女性被诊断为急性白血病并开始接受治疗，随后出现严重血小板减少症。尽管输注了富含血小板血浆、人类白细胞抗原（HLA）相匹配且HPA-1a阴性的血小板，但血小板计数并未增加。检查发现存在抗HPA-1a抗体。当输血后紫癜的诊断得到充分证实时，她已经发生了致命的脑出血。