性别、遗传学与镇痛：理解疼痛缓解反应的差异。
Gender, genetics, and analgesia: understanding the differences in response to pain relief.
作者信息
Packiasabapathy Senthil, Sadhasivam Senthilkumar
机构信息
Department of Anesthesia, Riley Hospital for Children at Indiana University Health, Indianapolis, IN, USA,
出版信息
J Pain Res. 2018 Nov 8;11:2729-2739. doi: 10.2147/JPR.S94650. eCollection 2018.
Abstract
Genetic variations and gender contribute significantly to the large interpatient variations in opioid-related serious adverse effects and differences in pain relief with other analgesics. Opioids are the most commonly used analgesics to relieve moderate-to-severe postoperative pain. Narrow therapeutic index and unexplained large interpatient variations in opioid-related serious adverse effects and analgesia negatively affect optimal perioperative outcomes. In surgical, experimental, chronic, and neuropathic pain models, females have been reported to have more pain than males. This review focuses on literature evidence of differences in pain relief due to multiple genetic variations and gender of the patient.
摘要
基因变异和性别在与阿片类药物相关的严重不良反应以及其他镇痛药在疼痛缓解方面的差异中，对患者间的巨大差异有显著影响。阿片类药物是缓解中重度术后疼痛最常用的镇痛药。治疗指数狭窄以及与阿片类药物相关的严重不良反应和镇痛效果存在无法解释的患者间巨大差异，对围手术期的最佳结局产生负面影响。在手术、实验性、慢性和神经性疼痛模型中，据报道女性比男性疼痛更严重。本综述重点关注因多种基因变异和患者性别导致的疼痛缓解差异的文献证据。
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