一个单一的 AT-GC 交换可以调节电荷转移诱导的 p53-DNA 解离。
A single AT-GC exchange can modulate charge transfer-induced p53-DNA dissociation.
机构信息
Department of Chemistry, Duke University, Durham, North Carolina 27708, USA.
出版信息
Chem Commun (Camb). 2018 Dec 20;55(2):206-209. doi: 10.1039/c8cc09048c.
Abstract
Using molecular dynamics simulations and electronic structure theory, we shed light on the charge dynamics that causes the differential interaction of tumor suppressor protein p53 with the p21 and Gadd45 genes in response to oxidative stress. We show that the sequence dependence of this selectivity results from competing charge transfer to the protein and through the DNA, with implications on the use of genome editing tools to influence the p53 regulatory function.
摘要
利用分子动力学模拟和电子结构理论，我们揭示了导致肿瘤抑制蛋白 p53 与 p21 和 Gadd45 基因在应对氧化应激时产生差异相互作用的电荷动力学。我们表明，这种选择性的序列依赖性源于竞争电荷转移到蛋白质和通过 DNA，这对利用基因组编辑工具来影响 p53 调节功能有影响。
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