平面细胞极性：两种遗传系统使用一种机制来读取梯度。

Planar cell polarity: two genetic systems use one mechanism to read gradients.

机构信息

Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK

Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.

出版信息

Development. 2018 Dec 10;145(23):dev168229. doi: 10.1242/dev.168229.

DOI:10.1242/dev.168229

PMID:30530515

Abstract

Our aim in this short Primer is to explain the principles of planar cell polarity (PCP) in animal development. The literature in this small field is complex and specialized, but we have extracted a simple and central story from it. We explain our hypothesis that polarity, initially cued by the direction of slope of a multicellular gradient, is interpreted at the cellular level so that each cell becomes molecularly polarised. The mechanism involves a comparison between a cell and its neighbours. To achieve this comparison there are (at least) two disparate and independent molecular systems, each depending on molecular bridges that span between neighbouring cells. Even though the two systems are made up of different molecules, we argue that both systems function in a logically equivalent way.

摘要

我们在这个简短入门中旨在解释动物发育中平面细胞极性（PCP）的原理。这个小领域的文献很复杂且专业化，但我们从中提取了一个简单而核心的故事。我们提出了一个假设，即极性最初由多细胞梯度的斜率方向提示，然后在细胞水平上进行解释，以使每个细胞在分子水平上极化。该机制涉及细胞与其相邻细胞之间的比较。为了实现这种比较，至少有两个不同的和独立的分子系统，每个系统都依赖于跨越相邻细胞的分子桥。尽管这两个系统由不同的分子组成，但我们认为两个系统都以逻辑等效的方式发挥作用。