[通过全球风险评估法评估墨西哥女性激素状态与心血管风险的关联]
[Asociación del estado hormonal con el riesgo cardiovascular evaluado por Globorisk en mujeres mexicanas].
作者信息
González-Escudero Eduardo, Basurto-Acevedo Lourdes, Barrera-Hernández Susana, Díaz-Martínez Alma, Sánchez-Huerta Lucero, Hernández-González Oswaldo, Santiago-Jiménez Gerardo, González-Quintana Víctor Manuel, Rodríguez-Luna Ana Karen, González-Chávez Antonio
机构信息
Instituto Mexicano del Seguro Social, Centro Médico Nacional, Hospital de Especialidades. Ciudad de México, México.
Instituto Politécnico Nacional, Escuela Superior de Medicina. Ciudad de México, México.
出版信息
Gac Med Mex. 2018;154(6):638-644. doi: 10.24875/GMM.18004104.
INTRODUCTION
Cardiovascular disease is the main cause of mortality worldwide. In women, its incidence increases at the sixth decade of life, coinciding with postmenopause. Whether this effect is due to menopause-related hormonal changes is not known.
OBJECTIVE
To evaluate the differences in cardiovascular risk in pre- and postmenopausal women by means of the Globorisk risk scale, the triglyceride/high-density lipoproteins cholesterol (Tg/HDL-C) ratio and metabolic syndrome (MS) criteria.
METHOD
Cross-sectional study that included 408 women from 40 to 60 years of age; anthropometric measurements and biochemical determinations were performed. The participants were classified as premenopausal and postmenopausal. Cardiovascular risk was assessed using the MS criteria, the Globorisk risk calculator and the Tg/HDL-C ratio.
RESULTS
Postmenopausal women showed a significant increase in waist circumference, total cholesterol and triglycerides in comparison with premenopausal women. Significant associations were found between hormonal state and Globorisk measured cardiovascular risk (OR = 2.50; 95 % CI = 1.67-3.74) and the Tg/HDL-C ratio (OR = 1.66; 95 % CI = 1.09-2.52).
CONCLUSION
Cardiovascular risk factors have a higher prevalence in postmenopause. The Globorisk scale and Tg/HDL-C ratio identify cardiovascular risk in postmenopausal women.
引言
心血管疾病是全球主要的死亡原因。在女性中，其发病率在生命的第六个十年增加，与绝经后期相吻合。这种影响是否归因于绝经相关的激素变化尚不清楚。
目的
通过全球风险量表、甘油三酯/高密度脂蛋白胆固醇（Tg/HDL-C）比值和代谢综合征（MS）标准，评估绝经前和绝经后女性心血管风险的差异。
方法
横断面研究纳入了408名40至60岁的女性；进行了人体测量和生化测定。参与者被分为绝经前和绝经后。使用MS标准、全球风险计算器和Tg/HDL-C比值评估心血管风险。
结果
与绝经前女性相比，绝经后女性的腰围、总胆固醇和甘油三酯显著增加。在激素状态与全球风险量表测量的心血管风险（OR = 2.50；95% CI = 1.67 - 3.74）和Tg/HDL-C比值（OR = 1.66；95% CI = 1.09 - 2.52）之间发现了显著关联。
结论
心血管危险因素在绝经后期的患病率更高。全球风险量表和Tg/HDL-C比值可识别绝经后女性的心血管风险。
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