中性粒细胞与淋巴细胞比值与心血管疾病风险：系统评价与荟萃分析。
Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis.
机构信息
Section for Clinical Epidemiology and Biostatistics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Division of Cardiovascular Medicine, Department of Medicine, Faculty of Medicine, HRH Princess Maha Chakri Sirindhorn Medical Center, Srinakharinwirot University, Nakhon Nayok, Thailand.
出版信息
Biomed Res Int. 2018 Nov 11;2018:2703518. doi: 10.1155/2018/2703518. eCollection 2018.
OBJECTIVE
This systematic review aimed to measure the association between neutrophil lymphocyte ratio (NLR) and cardiovascular disease (CVD) risk.
METHODS
Relevant studies were identified from Medline and Scopus databases. Observational studies with NLR as a study factor were eligible for review. The outcomes of interest were any type of CVD including acute coronary syndrome, coronary artery disease, stroke, or a composite of these cardiovascular events. Mean differences in NLR between CVD and non-CVD patients were pooled using unstandardized mean difference (USMD). Odds ratios of CVD between high and low NLR groups were pooled using a random effects model.
RESULTS
Thirty-eight studies (n=76,002) were included. High NLR was significantly associated with the risks of CAD, ACS, stroke, and composite cardiovascular events with pooled ORs of 1.62 (95% CI: 1.38-1.91), 1.64 (95% CI: 1.30, 2.05), 2.36 (95% CI: 1.44, 2.89), and 3.86 (95% CI: 1.73, 8.64), respectively. In addition, mean NLRs in CAD, ACS, and stroke patients were significantly higher than in control groups.
CONCLUSION
High NLR was associated with CAD, ACS, stroke, and composite cardiovascular events. Therefore, NLR may be a useful CVD biomarker.
目的
本系统评价旨在衡量中性粒细胞与淋巴细胞比值（NLR）与心血管疾病（CVD）风险之间的关联。
方法
从 Medline 和 Scopus 数据库中确定相关研究。纳入 NLR 作为研究因素的观察性研究符合本综述的纳入标准。感兴趣的结局是任何类型的 CVD，包括急性冠状动脉综合征、冠状动脉疾病、中风或这些心血管事件的综合表现。使用未标准化均数差（USMD）汇总 CVD 患者和非 CVD 患者 NLR 之间的差异。使用随机效应模型汇总 NLR 高低分组之间 CVD 的比值比（OR）。
结果
共纳入 38 项研究（n=76002）。高 NLR 与 CAD、ACS、中风和复合心血管事件的风险显著相关，汇总 OR 分别为 1.62（95%CI：1.38-1.91）、1.64（95%CI：1.30，2.05）、2.36（95%CI：1.44，2.89）和 3.86（95%CI：1.73，8.64）。此外，CAD、ACS 和中风患者的 NLR 均值明显高于对照组。
结论
高 NLR 与 CAD、ACS、中风和复合心血管事件相关。因此，NLR 可能是一种有用的 CVD 生物标志物。
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