一种与DNA光解酶形成的体内复合物可阻断针对大肠杆菌中胸腺嘧啶 - 胞嘧啶二聚体的紫外线诱变。
An in vivo complex with DNA photolyase blocks UV mutagenesis targeted at a thymine-cytosine dimer in Escherichia coli.
作者信息
Ruiz-Rubio M, Yamamoto K, Bockrath R
机构信息
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis 46223.
出版信息
J Bacteriol. 1988 Nov;170(11):5371-4. doi: 10.1128/jb.170.11.5371-5374.1988.
Abstract
UV mutation frequency responses for two types of Escherichia coli prototrophic mutant were measured. Only the response associated with a mutation targeted by a thymine-cytosine pyrimidine dimer was reduced in the dark in cells with amplified DNA photolyase. This specific reduction is attributed to the interruption of mutational DNA synthesis by a photolyase complex at the targeting dimer.
摘要
对两种类型的大肠杆菌原养型突变体的紫外线突变频率反应进行了测量。在具有扩增的DNA光解酶的细胞中，只有与胸腺嘧啶 - 胞嘧啶嘧啶二聚体靶向的突变相关的反应在黑暗中降低。这种特异性降低归因于光解酶复合物在靶向二聚体处对突变性DNA合成的中断。
相似文献
1
An in vivo complex with DNA photolyase blocks UV mutagenesis targeted at a thymine-cytosine dimer in Escherichia coli.
J Bacteriol. 1988 Nov;170(11):5371-4. doi: 10.1128/jb.170.11.5371-5374.1988.
2
Accelerated deamination of cytosine residues in UV-induced cyclobutane pyrimidine dimers leads to CC-->TT transitions.
Biochemistry. 1996 Aug 6;35(31):10172-81. doi: 10.1021/bi960001x.
3
Escherichia coli DNA photolyase stimulates uvrABC excision nuclease in vitro.
Proc Natl Acad Sci U S A. 1984 Dec;81(23):7397-401. doi: 10.1073/pnas.81.23.7397.
4
Utilization of DNA photolyase, pyrimidine dimer endonucleases, and alkali hydrolysis in the analysis of aberrant ABC excinuclease incisions adjacent to UV-induced DNA photoproducts.
Nucleic Acids Res. 1987 Feb 11;15(3):1227-43. doi: 10.1093/nar/15.3.1227.
5
6
Binding of Escherichia coli DNA photolyase to UV-irradiated DNA.
Biochemistry. 1985 Apr 9;24(8):1849-55. doi: 10.1021/bi00329a007.
7
Photoreversal of DNA unwinding caused by pyrimidine dimers.
Biochimie. 1982 Aug-Sep;64(8-9):665-8. doi: 10.1016/s0300-9084(82)80107-7.
8
DNA photolyase in E. coli: effects on UV mutagenesis by plasmids expressing the phr gene.
Mutat Res. 1989 Aug;226(4):259-62. doi: 10.1016/0165-7992(89)90079-1.
9
Effect of base, pentose, and phosphodiester backbone structures on binding and repair of pyrimidine dimers by Escherichia coli DNA photolyase.
Biochemistry. 1991 Sep 3;30(35):8623-30. doi: 10.1021/bi00099a019.
10
DNA photolyase repairs the trans-syn cyclobutane thymine dimer.
Biochemistry. 1993 Jul 20;32(28):7065-8. doi: 10.1021/bi00079a001.
引用本文的文献
1
Characterization of endonuclease III (nth) and endonuclease VIII (nei) mutants of Escherichia coli K-12.
J Bacteriol. 1997 Jun;179(11):3783-5. doi: 10.1128/jb.179.11.3783-3785.1997.
2
Mutation frequency decline in Escherichia coli. II. Kinetics support the involvement of transcription-coupled excision repair.
Mol Gen Genet. 1995 Dec 20;249(6):591-9. doi: 10.1007/BF00418028.
3
Inactivation of lacZ gene expression by UV light and bound DNA photolyase implies formation of extended complexes in the genomes of specific Escherichia coli strains.
Mol Gen Genet. 1991 Aug;228(1-2):249-57. doi: 10.1007/BF00282473.
4
Mechanism of SOS mutagenesis of UV-irradiated DNA: mostly error-free processing of deaminated cytosine.
Proc Natl Acad Sci U S A. 1992 Feb 15;89(4):1159-63. doi: 10.1073/pnas.89.4.1159.
5
Mutagenesis after exposure of bacteria to ultraviolet light and delayed photoreversal.
Mol Gen Genet. 1992 Jun;233(3):331-6. doi: 10.1007/BF00265428.
6
Dissection of functional domains in Escherichia coli DNA photolyase by linker-insertion mutagenesis.
Mol Gen Genet. 1992 Mar;232(1):1-6. doi: 10.1007/BF00299129.
7
RexAB proteins of bacteriophage lambda enhance the effect of photolyase-dimer complexes on lacZ gene expression in Escherichia coli.
Mol Gen Genet. 1992 Feb;231(3):480-4. doi: 10.1007/BF00292719.
本文引用的文献
1
Thermal resistance to photoreactivation of specific mutations potentiated in E. coli B/r ung by ultraviolet light.
Mol Gen Genet. 1981;182(1):7-11. doi: 10.1007/BF00422759.
2
UV-mutagenesis at a cloned target sequence: converted suppressor mutation is insensitive to mutation frequency decline regardless of the gene orientation.
Mutat Res. 1984 Nov-Dec;132(5-6):143-52. doi: 10.1016/0167-8817(84)90032-4.
3
Escherichia coli DNA photolyase stimulates uvrABC excision nuclease in vitro.
Proc Natl Acad Sci U S A. 1984 Dec;81(23):7397-401. doi: 10.1073/pnas.81.23.7397.
4
Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli.
Microbiol Rev. 1984 Mar;48(1):60-93. doi: 10.1128/mr.48.1.60-93.1984.
5
Amelioration of the ultraviolet sensitivity of an Escherichia coli recA mutant in the dark by photoreactivating enzyme.
Mol Gen Genet. 1983;190(3):511-5. doi: 10.1007/BF00331084.
6
A multicopy phr-plasmid increases the ultraviolet resistance of a recA strain of Escherichia coli.
Mutat Res. 1984 Jan;131(1):11-8. doi: 10.1016/0167-8817(84)90042-7.
7
Mutagenic repair in Escherichia coli. X. The umuC gene product may be required for replication past pyrimidine dimers but not for the coding error in UV-mutagenesis.
Mol Gen Genet. 1984;196(2):364-6. doi: 10.1007/BF00328073.
8
Analysis of photoenzymatic repair of UV lesions in DNA by single flashes. IV. Mutations affecting the number of photoreactivating enzyme molecules in E. coli cells.
Mutat Res. 1969 Sep-Oct;8(2):411-5. doi: 10.1016/0027-5107(69)90019-0.
9
Binding of Escherichia coli DNA photolyase to UV-irradiated DNA.
Biochemistry. 1985 Apr 9;24(8):1849-55. doi: 10.1021/bi00329a007.
10
Photoreactivation of UV damage in Escherichia coli uvrA6: lethality is more effectively reversed than either premutagenic lesions or SOS induction.
Mutat Res. 1985 Jul;146(1):33-42. doi: 10.1016/0167-8817(85)90052-5.
Zotero 插件