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气道正压通气治疗能否改善睡眠质量?

Does Positive Airway Pressure Therapy Result in Improved Sleep Quality?

作者信息

Stepnowsky Carl, Zamora Tania, Edwards Christine

机构信息

Health Services Research & Development Unit, Veterans Affairs San Diego Healthcare System, San Diego, USA.

Department of Medicine, University of California, San Diego, USA.

出版信息

Health (Irvine Calif). 2014 Oct;6(18):2416-2424. doi: 10.4236/health.2014.618278.

Abstract

INTRODUCTION

Positive airway pressure (PAP) therapy is the gold-standard for obstructive sleep apnea (OSA) management. While it is known that PAP is efficacious for controlling breathing events during sleep when it is worn at the right pressure for the amount of time prescribed, there is less clear data on how well it improves sleep quality. There are few studies that have examined the effectiveness of PAP therapy on sleep quality.

METHODS

OSA participants ( = 241) from a larger trial examining a PAP adherence were included. Participants were provided with PAP instruction and followed at 2 months and 4 months. PAP adherence was measured as the number of hours per night at prescribed pressure, an objective measure of treatment adherence. The Pittsburgh Sleep Quality Index (PSQI) was used as the primary measure of sleep quality.

RESULTS

The PSQI was significantly correlated with PAP adherence at both the 2-month and 4-month time points, such that lower sleep quality was associated with lower PAP use. This finding held for the sleep disturbance subscale of the PSQI. Over 55% of those using PAP therapy at the 4-month time point continued to report significantly disturbed sleep.

DISCUSSION

This study shows that PAP therapy does not appear to improve sleep quality to a degree that would be expected. Over half of those patients using PAP therapy still experienced disturbed sleep. Whether the disturbed sleep is directly attributable to the PAP device itself or to disturbed sleep secondary to uncontrolled OSA when PAP is not worn is worthy of further investigation.

摘要

引言

气道正压通气(PAP)疗法是阻塞性睡眠呼吸暂停(OSA)管理的金标准。虽然已知当以规定的压力佩戴规定的时间时,PAP在睡眠期间控制呼吸事件方面是有效的,但关于它在多大程度上改善睡眠质量的数据尚不清楚。很少有研究考察PAP疗法对睡眠质量的有效性。

方法

纳入了一项更大规模试验中检查PAP依从性的OSA参与者(n = 241)。为参与者提供PAP使用指导,并在2个月和4个月时进行随访。PAP依从性通过每晚在规定压力下的佩戴小时数来衡量,这是一种治疗依从性的客观指标。匹兹堡睡眠质量指数(PSQI)被用作睡眠质量的主要衡量指标。

结果

在2个月和4个月的时间点,PSQI与PAP依从性均显著相关,即睡眠质量越低,PAP使用时间越少。这一发现适用于PSQI的睡眠干扰子量表。在4个月时间点使用PAP疗法的患者中,超过55%的人仍报告睡眠严重受扰。

讨论

这项研究表明,PAP疗法似乎并未在预期程度上改善睡眠质量。超过一半使用PAP疗法的患者仍经历睡眠受扰。睡眠受扰是直接归因于PAP设备本身,还是由于未佩戴PAP时OSA未得到控制而导致的继发性睡眠受扰,值得进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4240/6287612/13edff6c3d8c/nihms-994296-f0001.jpg

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