基于金黄色葡萄球菌 5 型和 8 型荚膜多糖的 D-岩藻糖基-N-乙酰基-D-甘露糖胺二糖的合成。
Synthesis of D-FucNAc-D-ManNAcA Disaccharides Based On the Capsular Polysaccharides Staphylococcus aureus Type 5 and 8.
机构信息
Department of Chemistry and Biochemistry , University of Missouri-St. Louis , One University Boulevard , St. Louis , Missouri 63121 , United States.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy , Mahidol University , 447 Sri-Ayuddhaya Road , Rajathevee, Bangkok 10400 , Thailand.
出版信息
J Org Chem. 2019 Jan 4;84(1):216-227. doi: 10.1021/acs.joc.8b02612. Epub 2018 Dec 26.
To gain a better understanding of the conjugation chemistry taking place at the interface of the capsular polysaccharide repeating units, described herein is the synthesis of two disaccharides. These disaccharides correspond to the connection point of the repeating units of capsular polysaccharide S. aureus serotype 5 (CP5) and serotype 8 (CP8). As in our previous syntheses of trisaccharide repeating units, the potential propagation positions are blocked with methyl groups.
为了更好地了解荚膜多糖重复单元界面上的结合化学，本文介绍了两种二糖的合成。这些二糖对应于金黄色葡萄球菌血清型 5（CP5）和血清型 8（CP8）的荚膜多糖重复单元的连接点。与我们之前的三糖重复单元合成一样，潜在的聚合位置被甲基基团封闭。
Zotero 插件