胰岛素样生长因子 I 的调节及其在骨骼肌中的作用。

Insulin-Like Growth Factor I Regulation and Its Actions in Skeletal Muscle.

机构信息

Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida, Gainesville, Florida, USA.

出版信息

Compr Physiol. 2018 Dec 13;9(1):413-438. doi: 10.1002/cphy.c180010.

DOI:10.1002/cphy.c180010

PMID:30549022

Abstract

The insulin-like growth factor (IGF) pathway is essential for promoting growth and survival of virtually all tissues. It bears high homology to its related protein insulin, and as such, there is an interplay between these molecules with regard to their anabolic and metabolic functions. Skeletal muscle produces a significant proportion of IGF-1, and is highly responsive to its actions, including increased muscle mass and improved regenerative capacity. In this overview, the regulation of IGF-1 production, stability, and activity in skeletal muscle will be described. Second, the physiological significance of the forms of IGF-1 produced will be discussed. Last, the interaction of IGF-1 with other pathways will be addressed. © 2019 American Physiological Society. Compr Physiol 9:413-438, 2019.

摘要

胰岛素样生长因子（IGF）途径对于促进几乎所有组织的生长和存活至关重要。它与相关蛋白胰岛素具有高度同源性，因此，这些分子在它们的合成代谢和代谢功能方面存在相互作用。骨骼肌产生大量的 IGF-1，并且对其作用高度敏感，包括增加肌肉质量和改善再生能力。在本综述中，将描述骨骼肌中 IGF-1 的产生、稳定性和活性的调节。其次，将讨论产生的 IGF-1 形式的生理意义。最后，将解决 IGF-1 与其他途径的相互作用。© 2019 美国生理学会。综合生理学 9：413-438，2019。