褪黑素通过调节凋亡和自噬改善柯萨奇病毒B3诱导的心肌炎。
Melatonin Ameliorates Coxsackievirus B3-Induced Myocarditis by Regulating Apoptosis and Autophagy.
作者信息
Sang Yimiao, Gu Xiaohong, Pan Lulu, Zhang Chunxiang, Rong Xing, Wu Tingting, Xia Tianhe, Li Yuechun, Ge Lisha, Zhang Yuanhai, Chu Maoping
机构信息
Children's Heart Center, The Second Affiliated Hospital and Yuying Children's Hospital, Institute of Cardiovascular Development and Translational Medicine, Wenzhou Medical University, Wenzhou, China.
Department of Pediatrics, The First Affiliated Hospital of Zhejiang University, Hangzhou, China.
出版信息
Front Pharmacol. 2018 Dec 4;9:1384. doi: 10.3389/fphar.2018.01384. eCollection 2018.
Current therapeutics options for viral myocarditis are unsatisfactory. Melatonin (MLT), a hormone secreted by the pineal gland and other organs, has protective effects on ischemic heart injury. However, the potential therapeutic effect of MLT on viral myocarditis is unknown. In this study, we investigated the protective effect of MLT on viral myocarditis in a mouse model of myocarditis infected with coxsackievirus B3 (CVB3) and explored the probable mechanisms. Mice with CVB3-induced myocarditis displayed inflammatory cell infiltration and interstitial edema. MLT treatment significantly ameliorated the myocardial injuries. In addition, the rate of autophagy changed, although apoptosis was inhibited in mouse hearts following treatment with MLT. These results suggest that MLT has a strong therapeutic effect on acute viral myocarditis, which is associated with changes in autophagy and apoptosis in the heart. Thus, MLT could be a promising novel therapeutic approach against viral myocarditis.
目前病毒性心肌炎的治疗选择并不令人满意。褪黑素（MLT）是一种由松果体及其他器官分泌的激素，对缺血性心脏损伤具有保护作用。然而，MLT对病毒性心肌炎的潜在治疗效果尚不清楚。在本研究中，我们在感染柯萨奇病毒B3（CVB3）的小鼠心肌炎模型中研究了MLT对病毒性心肌炎的保护作用，并探讨了其可能的机制。CVB3诱导的心肌炎小鼠表现出炎症细胞浸润和间质水肿。MLT治疗显著改善了心肌损伤。此外，自噬率发生了变化，尽管MLT治疗后小鼠心脏中的细胞凋亡受到抑制。这些结果表明，MLT对急性病毒性心肌炎具有强大的治疗作用，这与心脏中自噬和细胞凋亡的变化有关。因此，MLT可能是一种有前景的抗病毒性心肌炎的新型治疗方法。
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