State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
New Drug Safety Evaluation Center, Institute of Materia Medica, Chinese Academy of Medical, Sciences & Peking Union Medical College, Beijing 100050, China.
Int J Mol Sci. 2018 Dec 23;20(1):55. doi: 10.3390/ijms20010055.
Environmental issues pose huge threats to public health, particularly the damage caused by fine particulate matter (PM). However, the mechanisms of injury require further investigation and medical materials that can protect the lungs from PM are needed. We have found that , a traditional Chinese medicine that has long been used to treat various ailments, is a good candidate to serve this purpose. To understand the mechanisms of PM-induced lung toxicity and the protective effects of , we established a rat model of lung injury via intratracheal instillation of artificial PM (aPM). Our results demonstrated that significantly protected against lung function decline and pathologic changes. Inflammation was ameliorated by suppression of to adjust the disturbed metabolic pathways induced by aPM, such as arginine and nitrogen metabolism and aminoacyl-tRNA biosynthesis, for 11 weeks. Our work found that metabolomics was a useful tool that contributed to further understanding of PM-induced respiratory system damage and provided useful information for further pharmacological research on , which may be valuable for therapeutic intervention.
环境问题对公众健康构成巨大威胁，尤其是细颗粒物（PM）造成的损害。然而，其损伤机制仍需进一步研究，需要寻找能保护肺部免受 PM 侵害的医学材料。我们发现，一种传统中药，长期以来一直被用于治疗各种疾病，是满足这一需求的良好候选药物。为了了解 PM 诱导的肺毒性的机制和 的保护作用，我们通过气管内滴注人工 PM（aPM）建立了大鼠肺损伤模型。结果表明， 能显著保护肺功能下降和病理变化。通过抑制 来调节 aPM 诱导的代谢途径的紊乱，如精氨酸和氮代谢以及氨酰-tRNA 生物合成，炎症得到改善，持续 11 周。我们的工作发现，代谢组学是一种有用的工具，可以帮助进一步了解 PM 引起的呼吸系统损伤，并为 进一步的药理学研究提供有用信息，这对于治疗干预可能具有重要价值。
Zotero 插件
