[具体物质名称]和[具体物质名称]对腺嘌呤诱导的大鼠慢性肾衰竭的潜在治疗作用及其植物化学分析

Potential therapeutic effects of and on adenine-induced chronic renal failure in rats and their phytochemical analysis.

作者信息

Li Ling, Zhang Tong, Li Chunru, Xie Lu, Li Ning, Hou Tianling, Wang Yuqin, Wang Bing

机构信息

Experiment Center for Teaching and Learning, Shanghai University of Traditional Chinese Medicine, Shanghai, China,

Zhejiang BioAsia Pharmaceutical Co., Ltd., Pinghu, Zhejiang, China,

出版信息

Drug Des Devel Ther. 2018 Dec 19;13:103-117. doi: 10.2147/DDDT.S180543. eCollection 2019.

BACKGROUND

Natural () has been utilized extensively in traditional Chinese medicine to treat chronic renal diseases, heart palpitations, infantile convulsions, and dizziness. However, given its slow growth and immoderate exploitation, resources have been severely depleted. By contrast, (), as the anamorph stage of , is easy to cultivate, and this kind of cultivated has good and controllable quality.

PURPOSE

This study aimed to compare the therapeutic effects of and on adenine-induced chronic renal failure (CRF) rats. In accordance with the aforementioned studies, our work subsequently analyzed the intrinsic relationships between the efficacy and pharmacodynamic substances of and to conclude whether or not could be used as an alternative to in treating CRF.

METHODS

Rats were administered with (1.0 g/kg) or (1.0 g/kg) by gavage for 4 weeks. Furthermore, we applied Fourier transform infrared spectroscopy, gas chromatography-mass spectrometry, liquid chromatography-tandem mass spectrometry, and ultraviolet spectrophotometry to comprehensively detect and analyze the chemical constituent differences from ten batches each of and .

RESULTS

This study revealed that both and exerted obvious therapeutic effects on CRF and were more consistent with their chemical compositions.

CONCLUSION

can be used as an alternative to for treating CRF to cater to market demands.

背景

天然（此处原文缺失具体名称）在中国传统医学中已被广泛用于治疗慢性肾病、心悸、小儿惊厥和头晕。然而，由于其生长缓慢且过度开发，（此处原文缺失具体名称）资源已严重枯竭。相比之下，（此处原文缺失具体名称）作为（此处原文缺失具体名称）的无性型阶段，易于培养，且这种培养的（此处原文缺失具体名称）具有良好且可控的质量。

目的

本研究旨在比较（此处原文缺失具体名称）和（此处原文缺失具体名称）对腺嘌呤诱导的慢性肾衰竭（CRF）大鼠的治疗效果。根据上述研究，我们的工作随后分析了（此处原文缺失具体名称）和（此处原文缺失具体名称）的疗效与药效物质之间的内在关系，以确定（此处原文缺失具体名称）是否可作为（此处原文缺失具体名称）治疗CRF的替代品。

方法

大鼠通过灌胃给予（此处原文缺失具体名称）（1.0 g/kg）或（此处原文缺失具体名称）（1.0 g/kg），持续4周。此外，我们应用傅里叶变换红外光谱、气相色谱 - 质谱联用、液相色谱 - 串联质谱和紫外分光光度法，全面检测和分析来自（此处原文缺失具体名称）和（此处原文缺失具体名称）各十批次的化学成分差异。