Department of Pharmacology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
J Dermatol. 2019 Mar;46(3):177-185. doi: 10.1111/1346-8138.14749. Epub 2018 Dec 27.
Chronic itch with an itch-scratch vicious circle is a significant problem in a large amount of diseases. Some of these diseases, such as psoriasis, atopic dermatitis, prurigo nodularis, Sézary syndrome, uremic pruritus, diabetes and jaundice, are common. For a very long time, chronic itch has been a thorny problem with few effective treatments. Because of this, itch researchers and dermatologists seek to find the mechanisms among chronic itch, inflammatory cytokines and neurons. As an immediate area of research focus, we are going to find the peripheral cross-talk between neurons and skin cells. Two receptors, named transient receptor potential channel vanilloid 1 and transient receptor potential channel ankyrin transmembrane protein 1, have been shown to play important roles in chronic itch. Many advances have been made so far this decade. This review talks about the updated mechanism of itch-related inflammatory cytokines via transient receptor potential channels in cutaneous chronic itch and corresponding diseases. The search for itch-related inflammatory mediators and the structure of transient receptor potential channels this decade could deepen our understanding of the mechanism of itch and help us find more treatments of chronic itch in the future.
慢性瘙痒伴有瘙痒-搔抓恶性循环是大量疾病中的一个重大问题。其中一些疾病，如银屑病、特应性皮炎、结节性痒疹、蕈样肉芽肿、尿毒症瘙痒、糖尿病和黄疸，较为常见。长期以来，慢性瘙痒一直是一个棘手的问题，治疗方法很少。正因为如此，瘙痒研究人员和皮肤科医生试图寻找慢性瘙痒、炎症细胞因子和神经元之间的机制。作为一个立即的研究重点领域，我们将寻找神经元和皮肤细胞之间的外周串扰。已经表明，两种受体，即瞬时受体电位通道香草素 1 和瞬时受体电位通道锚蛋白 1，在慢性瘙痒中发挥重要作用。在过去的十年中已经取得了许多进展。本综述讨论了皮肤慢性瘙痒和相关疾病中瞬时受体电位通道相关炎症细胞因子的更新机制。这十年中对瘙痒相关炎症介质和瞬时受体电位通道结构的研究可以加深我们对瘙痒机制的理解，并有助于我们在未来找到更多治疗慢性瘙痒的方法。
